An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis

An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis

Item

http://www.wikidata.org/entity/Q34283717

Q34283717

about

On the predictive utility of animal models of osteoarthritis High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity Cannabinoid abuse and addiction: Clinical and preclinical findings Chemical probes of endocannabinoid metabolism FAAH inhibitors in the limelight, but regrettably Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems-A Novel Treatment Option for Chronic Pain Management The endocannabinoid system as a potential therapeutic target for pain modulation Preclinical Characterization of the FAAH Inhibitor JNJ-42165279 Latest advances in the discovery of fatty acid amide hydrolase inhibitors Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation A commentary on modelling osteoarthritis pain in small animals Key role of publication of clinical data for target validation.Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain.Interactions of Cannabinoids With Biochemical Substrates Endocannabinoids Have Opposing Effects On Behavioral Responses To Nociceptive And Non-nociceptive Stimuli.Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models.PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates.Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.Endocannabinoids and acute pain after total knee arthroplasty.Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice Efficacy, Tolerability, and Safety of Cannabinoid Treatments in the Rheumatic Diseases: A Systematic Review of Randomized Controlled Trials.Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity.Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model PET radiopharmaceuticals for probing enzymes in the brain A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation.Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold.Modulating the endocannabinoid system in human health and disease--successes and failures Increased anandamide uptake by sensory neurons contributes to hyperalgesia in a model of cancer pain A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase Screening Medications for the Treatment of Cannabis Use Disorder.Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain.A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs).Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system.Translational PK-PD modeling in pain.Endocannabinoid system and pain: an introduction.Ion channels and osteoarthritic pain: potential for novel analgesics.Anandamide in primary sensory neurons: too much of a good thing?

P2860

Q26781301-88BD9EEB-217F-4E9D-929B-36FFC271E41C Q26784030-D5E237FF-0CAD-4C53-8438-43CDD2D42C1F Q26851944-B4BDCEC8-7CB0-4907-A094-9506F3068A8D Q26863202-71C6C309-4BF9-4247-9906-1B9AE215DF38 Q28067151-6F764E92-63D3-4221-BFBD-0FFEF5AC6CF4 Q28067493-9CBEC08F-21D1-4BAC-83D1-EA6DBF52938D Q28247621-88A7E8F7-A35A-4036-870C-C160AD740A33 Q28271553-A1C14C96-7E16-409E-AE70-076770A1C2FD Q28287173-BDD150C4-C605-41C7-BAE4-A1DA3C569407 Q28300390-EBDFECFC-227F-4C07-AB20-B1DA68633A47 Q28393331-356AC2C3-4ED4-43E6-9955-A689CC32276C Q30432076-C55EB658-B2B0-4435-9AF8-32F838F16503 Q30984622-8033DD15-AE67-40C4-83C4-4E46328593EB Q33560467-82906375-A00D-4985-999D-893527902995 Q33758351-A9A806B3-2032-42B2-9499-EA1ABB8FD62A Q33919139-EA011C86-4258-45A1-A19C-263E3E4AC7E9 Q34390806-52F6BAF2-01DF-49E5-8403-0D42922CDB5B Q34473739-60AB79F5-8735-4EE0-B72F-089384DD4E37 Q34644485-BFB43A33-9F41-46BA-8F92-7E3DE2E9A6B2 Q34988278-EBA0DE7C-FE52-43F8-9E47-ED87A1FD5F7E Q35223920-534BB810-DD1A-4E13-9467-A069AF843E7A Q35835342-504CB0E0-59D1-477A-A776-981F218C2743 Q35846608-E1294370-D1C3-40E4-8908-A9ADFC950053 Q36003998-AA0F07F1-7309-4DF4-A609-9BE30EE5EAA2 Q36648880-90FDDD4C-9389-418C-B9F6-E2CE890BA593 Q36744213-9CE49A79-62CB-4744-B2D3-A180ABB55AB8 Q36769219-450736CB-7D0C-4315-94FE-3BAE0200B89A Q36823364-D5133404-F19F-4D19-BC0D-33359DF1D320 Q36926261-E8ED5D2E-0DA5-4CCF-9F56-C34D7F02F4E9 Q36933683-DB532D3C-25F1-4DF9-B9BC-DA26DA35D7FD Q37107118-1E02ED14-41B6-4723-ABA4-19A3EEDEE9E7 Q37115263-EBFEDB08-BC10-40F2-9FE0-7029990AEEEB Q37187618-8A6526D4-1EE4-45E6-A0F0-101C790A98A8 Q37323488-1B63EC5F-C3F9-460D-9257-C3AAEBC80AC8 Q37335452-84276255-204D-441F-A790-03DC8014DA71 Q38056397-F59C06CE-A288-4260-907D-C59A9E36998A Q38063813-B315924D-35C2-47AA-9737-E9634F2AD1E2 Q38154691-F18A4C87-56B6-431D-9020-D89A66434A06 Q38160393-92BD475C-ADAF-4252-8801-1BEDF5BBD5D5 Q38185073-9B77D9B6-CAFD-421D-90F6-3637D4F43CD9

P2860

An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis

Item

http://www.wikidata.org/entity/Q34283717

description

2012 nî lūn-bûn

@nan

2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu