Activation of factor VIII and mechanisms of cofactor action.
about
Domain organization of membrane-bound factor VIII.A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IXReplacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXaCofactor activity in factor VIIIa of the blood clotting pathway is stabilized by an interdomain bond between His281 and Ser524 formed in factor VIII.Lipid nanotechnologies for structural studies of membrane-associated proteinsA new recombinant factor VIII: from genetics to clinical use.Dimeric Organization of Blood Coagulation Factor VIII bound to Lipid Nanotubes.Molecular recognition mechanisms of thrombin.Epitope mapping factor VIII A2 domain by affinity-directed mass spectrometry: residues 497-510 and 584-593 comprise a discontinuous epitope for the monoclonal antibody R8B12.Factor VIII lacking the C2 domain retains cofactor activity in vitroEffects of replacement of factor VIII amino acids Asp519 and Glu665 with Val on plasma survival and efficacy in vivo.Soy phosphatidylinositol containing nanoparticle prolongs hemostatic activity of B-domain deleted factor VIII in hemophilia A mice.The molecular basis of factor V and VIII procofactor activationMapping the N-glycome of human von Willebrand factor.Blood coagulation factors V and VIII: Molecular Mechanisms of Procofactor Activation.Increasing hydrophobicity or disulfide bridging at the factor VIII A1 and C2 domain interface enhances procofactor stability.The role of P4-P3' residues flanking Arg336 in facilitating activated protein C-catalyzed cleavage and inactivation of factor VIIIaHemostatic Factors, APOL1 Risk Variants, and the Risk of ESRD in the Atherosclerosis Risk in Communities Study.The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin.Sequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function.Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis of bleeding and thrombotic diseases.A bipartite autoinhibitory region within the B-domain suppresses function in factor VP3-P3' residues flanking scissile bonds in factor VIII modulate rates of substrate cleavage and procofactor activation by thrombinThe anticoagulant protein C pathway.Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIaFactor VIIIa A2 subunit shows a high affinity interaction with factor IXa: contribution of A2 subunit residues 707-714 to the interaction with factor IXa.Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface.Acidic residues C-terminal to the A2 domain facilitate thrombin-catalyzed activation of factor VIII.Multimerin 1.Diagnosis of factor VIII deficiency.Identification of residues in the 558-loop of factor VIIIa A2 subunit that interact with factor IXaManagement of bleeding disorders: basic science.Factor VIII therapy for hemophilia A: current and future issues.Innovative approach for improved rFVIII concentrate.Recent advances in hemophilia B therapy.Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIaActivation, activity and inactivation of factor VIII in factor VIII products.Disulfide bond-stabilized factor VIII has prolonged factor VIIIa activity and improved potency in whole blood clotting assays.Characterization of coagulation factor synthesis in nine human primary cell typesBinding of recombinant human coagulation factor VIII to lipid nanotubes.
P2860
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P2860
Activation of factor VIII and mechanisms of cofactor action.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Activation of factor VIII and mechanisms of cofactor action.
@ast
Activation of factor VIII and mechanisms of cofactor action.
@en
Activation of factor VIII and mechanisms of cofactor action.
@nl
type
label
Activation of factor VIII and mechanisms of cofactor action.
@ast
Activation of factor VIII and mechanisms of cofactor action.
@en
Activation of factor VIII and mechanisms of cofactor action.
@nl
prefLabel
Activation of factor VIII and mechanisms of cofactor action.
@ast
Activation of factor VIII and mechanisms of cofactor action.
@en
Activation of factor VIII and mechanisms of cofactor action.
@nl
P1433
P1476
Activation of factor VIII and mechanisms of cofactor action.
@en
P2093
Philip J Fay
P356
10.1016/S0268-960X(03)00025-0
P577
2004-03-01T00:00:00Z