Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.
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Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinibCytochrome P450 3A Enzymes Catalyze the O6-Demethylation of Thebaine, a Key Step in Endogenous Mammalian Morphine BiosynthesisGomisin A is a Novel Isoform-Specific Probe for the Selective Sensing of Human Cytochrome P450 3A4 in Liver Microsomes and Living Cells.CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinomaEffects of CYP3A5 genetic polymorphism and smoking on the prognosis of non-small-cell lung cancer.Pharmacokinetic drug-drug interactions between 1,4-dihydropyridine calcium channel blockers and statins: factors determining interaction strength and relevant clinical risk management.Characterization of T-5 N-oxide formation as the first highly selective measure of CYP3A5 activityIn Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development.Developmental changes in the expression and function of cytochrome P450 3A isoforms: evidence from in vitro and in vivo investigations.Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism.Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of LapatinibA highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications.CYP3A5*3 polymorphism and cancer risk: a meta-analysis and meta-regression.A novel maturation function for clearance of the cytochrome P450 3A substrate midazolam from preterm neonates to adults.Metabolism and clinical pharmacokinetics of 2-methyl-n-(2'-(pyrrolidinyl-1-ylsulfonyl)-n-[1,1'-biphenyl]-4-yl)propran-1-amine: insights into monoamine oxidase- and CYP-mediated disposition by integration of in vitro ADME tools.The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5.Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors.Age-related Differences in CYP3A Abundance and Activity in the Liver of the Göttingen Minipig.In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes.
P2860
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P2860
Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Selective mechanism-based inac ...... A5 in the metabolism of drugs.
@ast
Selective mechanism-based inac ...... A5 in the metabolism of drugs.
@en
Selective mechanism-based inactivation of CYP3A4 by CYP3cide
@nl
type
label
Selective mechanism-based inac ...... A5 in the metabolism of drugs.
@ast
Selective mechanism-based inac ...... A5 in the metabolism of drugs.
@en
Selective mechanism-based inactivation of CYP3A4 by CYP3cide
@nl
prefLabel
Selective mechanism-based inac ...... A5 in the metabolism of drugs.
@ast
Selective mechanism-based inac ...... A5 in the metabolism of drugs.
@en
Selective mechanism-based inactivation of CYP3A4 by CYP3cide
@nl
P2093
P356
P1476
Selective mechanism-based inac ...... A5 in the metabolism of drugs.
@en
P2093
Christopher J Helal
Gregory S Walker
Kieran F Geoghegan
Michael A Zientek
Michael West
R Scott Obach
Robert L Walsky
Ruth Hyland
P304
P356
10.1124/DMD.112.045302
P577
2012-05-29T00:00:00Z