Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations. - Wikidata - wikimedia - TriplyDB

Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations.

Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations.

http://www.wikidata.org/entity/Q34288805

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CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits Genetic associations with lipoprotein subfraction measures differ by ethnicity in the multi-ethnic study of atherosclerosis (MESA).ATHENA: a tool for meta-dimensional analysis applied to genotypes and gene expression data to predict HDL cholesterol levels PHENOME-WIDE INTERACTION STUDY (PheWIS) IN AIDS CLINICAL TRIALS GROUP DATA (ACTG).Genetic distance as an alternative to physical distance for definition of gene units in association studies.Analysis pipeline for the epistasis search - statistical versus biological filtering.Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography.Dissection of additive, dominance, and imprinting effects for production and reproduction traits in Holstein cattle.Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels.Gene-based testing of interactions in association studies of quantitative traits A PLSPM-based test statistic for detecting gene-gene co-association in genome-wide association study with case-control design.Properties of local interactions and their potential value in complementing genome-wide association studies.Analysis of gene-gene interactions among common variants in candidate cardiovascular genes in coronary artery disease How genome-wide SNP-SNP interactions relate to nasopharyngeal carcinoma susceptibility.Analysis of multiple association studies provides evidence of an expression QTL hub in gene-gene interaction network affecting HDL cholesterol levels.Genome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local chromosomal interactions governing gene expression.Investigating the Role of Gene-Gene Interactions in TB Susceptibility.Genome-Wide Analysis of Gene-Gene and Gene-Environment Interactions Using Closed-Form Wald Tests Biology-Driven Gene-Gene Interaction Analysis of Age-Related Cataract in the eMERGE Network.Pathway Analysis Incorporating Protein-Protein Interaction Networks Identified Candidate Pathways for the Seven Common Diseases.Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium.Integration of biological networks and pathways with genetic association studies.Interaction between SNPs in the RXRA and near ANGPTL3 gene region inhibits apoB reduction after statin-fenofibric acid therapy in individuals with mixed dyslipidemia Polymorphisms involving gain or loss of CpG sites are significantly enriched in trait-associated SNPs A Novel Test for Detecting SNP-SNP Interactions in Case-Only Trio Studies A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family.Human dopamine transporter gene: differential regulation of 18-kb haplotypes Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia.Comparing GWAS Results of Complex Traits Using Full Genetic Model and Additive Models for Revealing Genetic Architecture.How Gene Networks Can Uncover Novel CVD Players.Biological knowledge-driven analysis of epistasis in human GWAS with application to lipid traits.The role of epistasis in the etiology of Polycystic Ovary Syndrome among Indian women: SNP-SNP and SNP-environment interactions.The role of gene polymorphisms in endometriosis.Approaching "phantom heritability" in psychiatry by hypothesis-driven gene-gene interactions.Confronting the missing epistasis problem: on the reproducibility of gene-gene interactions.A whole-genome simulator capable of modeling high-order epistasis for complex disease.Replication of endometriosis-associated single-nucleotide polymorphisms from genome-wide association studies in a Caucasian population.The Effect of Residing Altitude on Levels of High-Density Lipoprotein Cholesterol: A Pilot Study From the Omani Arab Population.Another Round of "Clue" to Uncover the Mystery of Complex Traits.

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Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations.

http://www.wikidata.org/entity/Q34288805

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Alon Keinan

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Andrew G Clark

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Ariel Brautbar

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Charles F Sing

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Li Ma

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A flexible and accurate genotype imputation method for the next generation of genome-wide association studies

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

Finding the missing heritability of complex diseases

Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation

The NCBI dbGaP database of genotypes and phenotypes

A map of human genome variation from population-scale sequencing

Biological, clinical and population relevance of 95 loci for blood lipids

PLINK: a tool set for whole-genome association and population-based linkage analyses

Haploview: analysis and visualization of LD and haplotype maps

Principal components analysis corrects for stratification in genome-wide association studies

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225086890

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HDL cholesterol

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3359971

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