p300-mediated tax transactivation from recombinant chromatin: histone tail deletion mimics coactivator function.
about
The HTLV-1 Tax interactomeThe bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcriptionNucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNAp53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300Role of accessory proteins of HTLV-1 in viral replication, T cell activation, and cellular gene expression.Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway.Activator-dependent p300 acetylation of chromatin in vitro: enhancement of transcription by disruption of repressive nucleosome-nucleosome interactionsThe central region of human T-cell leukemia virus type 1 Tax protein contains distinct domains involved in subunit dimerizationNucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14.The high-affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expressionThe complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription.Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat.Transcription regulatory complexes bind the human T-cell leukemia virus 5' and 3' long terminal repeats to control gene expression.Tax abolishes histone H1 repression of p300 acetyltransferase activity at the human T-cell leukemia virus type 1 promoter.Tax recruitment of CBP/p300, via the KIX domain, reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independentHistone chaperones, histone acetylation, and the fluidity of the chromogenomeHuman T-cell leukemia virus type 1 (HTLV-1) bZIP protein interacts with the cellular transcription factor CREB to inhibit HTLV-1 transcription.An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZEviction of linker histone H1 by NAP-family histone chaperones enhances activated transcriptionStructural characterization of histone H2A variants.The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.The coactivators CBP/p300 and the histone chaperone NAP1 promote transcription-independent nucleosome eviction at the HTLV-1 promoterHuman T-lymphotropic virus proteins and post-translational modification pathwaysDeacetylase inhibitors and the viral transactivator TaxBLV synergistically activate bovine leukemia virus gene expression via a cAMP-responsive element- and cAMP-responsive element-binding protein-dependent mechanism.The HBZ factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity.Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism.Preferential binding of the histone (H3-H4)2 tetramer by NAP1 is mediated by the amino-terminal histone tails.Tax-dependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1.Transcription factor binding and histone modifications on the integrated proviral promoter in human T-cell leukemia virus-I-infected T-cells.
P2860
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P2860
p300-mediated tax transactivation from recombinant chromatin: histone tail deletion mimics coactivator function.
description
2002 nî lūn-bûn
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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2002 թվականի հունվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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name
p300-mediated tax transactivat ...... n mimics coactivator function.
@ast
p300-mediated tax transactivat ...... n mimics coactivator function.
@en
p300-mediated tax transactivat ...... n mimics coactivator function.
@nl
type
label
p300-mediated tax transactivat ...... n mimics coactivator function.
@ast
p300-mediated tax transactivat ...... n mimics coactivator function.
@en
p300-mediated tax transactivat ...... n mimics coactivator function.
@nl
prefLabel
p300-mediated tax transactivat ...... n mimics coactivator function.
@ast
p300-mediated tax transactivat ...... n mimics coactivator function.
@en
p300-mediated tax transactivat ...... n mimics coactivator function.
@nl
P2093
P2860
P1476
p300-mediated tax transactivat ...... n mimics coactivator function.
@en
P2093
Jennifer K Nyborg
Paul J Laybourn
Sara A Georges
W Lee Kraus
P2860
P304
P356
10.1128/MCB.22.1.127-137.2002
P407
P577
2002-01-01T00:00:00Z