Stabilization of phage T4 lysozyme by engineered disulfide bonds
about
Lessons from the lysozyme of phage T4Simple evolutionary pathways to complex proteinsSimulating evolution by gene duplication of protein features that require multiple amino acid residuesIntramolecular isopeptide bonds give thermodynamic and proteolytic stability to the major pilin protein of Streptococcus pyogenesUse of a non-rigid region in T4 lysozyme to design an adaptable metal-binding siteEntropic stabilization of the tryptophan synthase alpha-subunit from a hyperthermophile, Pyrococcus furiosus. X-ray analysis and calorimetryStructural basis of thermostability. Analysis of stabilizing mutations in subtilisin BPN'Structure of a stabilizing disulfide bridge mutant that closes the active-site cleft of T4 lysozymeStructure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gatingStereoelectronic and steric effects in side chains preorganize a protein main chainCysteine-free rop: A four-helix bundle core mutant has wild-type stability and structure but dramatically different unfolding kineticsIntroduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogenStructural and Mechanistic Studies of Pesticin, a Bacterial Homolog of Phage LysozymesMechanism of Protein Kinetic Stabilization by Engineered Disulfide CrosslinksStructural mimicry of a native protein by a minimized binding domainContribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease AModulating protein folding rates in vivo and in vitro by side-chain interactions between the parallel beta strands of green fluorescent protein.Insertion of foreign T cell epitopes in human tumor necrosis factor alpha with minimal effect on protein structure and biological activity.Geofold: topology-based protein unfolding pathways capture the effects of engineered disulfides on kinetic stability.Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C: use of engineered disulfide bridges, antibodies, and carboxymethylpapain to stabilize the monomeric form of cystatin C.Effects of disulfide bonds on folding behavior and mechanism of the beta-sheet protein tendamistat.Disulfide by Design 2.0: a web-based tool for disulfide engineering in proteinsComputationally designed libraries for rapid enzyme stabilization.Stabilization of cyclohexanone monooxygenase by a computationally designed disulfide bond spanning only one residue.Independent of their localization in protein the hydrophobic amino acid residues have no effect on the molten globule state of apomyoglobin and the disulfide bond on the surface of apomyoglobin stabilizes this intermediate stateModified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis.Additional disulfide bonds in insulin: Prediction, recombinant expression, receptor binding affinity, and stability.Strong DNA binding by covalently linked dimeric Lac headpiece: evidence for the crucial role of the hinge helices.Enhancing protein stability with extended disulfide bonds.Substrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-2.alpha-Amylases and approaches leading to their enhanced stability.Hydrophobic core repacking and aromatic-aromatic interaction in the thermostable mutant of T4 lysozyme Ser 117-->PheCrystallization and preliminary X-ray crystallographic analysis of the oxysterol-binding protein Osh3 from Saccharomyces cerevisiae.Genetic fusion of subunits of a dimeric protein substantially enhances its stability and rate of foldingExperimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptorsProbing residue-specific interactions in the stabilization of proteins using high-resolution NMR: a study of disulfide bond compensation.Knotted and topologically complex proteins as models for studying folding and stability.Engineering de novo disulfide bond in bacterial α-type carbonic anhydrase for thermostable carbon sequestrationThe role of thiols and disulfides on protein stability.Implication of disulfide bridge induced thermal reversibility, structural and functional stability for luciferase.
P2860
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P2860
Stabilization of phage T4 lysozyme by engineered disulfide bonds
description
1989 nî lūn-bûn
@nan
1989 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Stabilization of phage T4 lysozyme by engineered disulfide bonds
@ast
Stabilization of phage T4 lysozyme by engineered disulfide bonds
@en
Stabilization of phage T4 lysozyme by engineered disulfide bonds
@nl
type
label
Stabilization of phage T4 lysozyme by engineered disulfide bonds
@ast
Stabilization of phage T4 lysozyme by engineered disulfide bonds
@en
Stabilization of phage T4 lysozyme by engineered disulfide bonds
@nl
prefLabel
Stabilization of phage T4 lysozyme by engineered disulfide bonds
@ast
Stabilization of phage T4 lysozyme by engineered disulfide bonds
@en
Stabilization of phage T4 lysozyme by engineered disulfide bonds
@nl
P2093
P2860
P356
P1476
Stabilization of phage T4 lysozyme by engineered disulfide bonds
@en
P2093
B W Matthews
M Matsumura
W J Becktel
P2860
P304
P356
10.1073/PNAS.86.17.6562
P407
P577
1989-09-01T00:00:00Z