An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability. - Wikidata - wikimedia - TriplyDB

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

http://www.wikidata.org/entity/Q34300731

about

A self-sequestered calmodulin-like Ca²⁺ sensor of mitochondrial SCaMC carrier and its implication to Ca²⁺-dependent ATP-Mg/P(i) transport Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5 Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart Solution NMR structure of the C-terminal EF-hand domain of human cardiac sodium channel NaV1.5 Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic-clonic seizures Reactive Oxygen Species, Endoplasmic Reticulum Stress and Mitochondrial Dysfunction: The Link with Cardiac Arrhythmogenesis Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels Solution Structure of the NaV1.2 C-terminal EF-hand Domain Crystallographic basis for calcium regulation of sodium channels Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias Vasa recta voltage-gated Na+ channel Nav1.3 is regulated by calmodulin Posthearing Ca(2+) currents and their roles in shaping the different modes of firing of spiral ganglion neurons Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes Cardiac Na Channels: Structure to Function Sodium channel carboxyl-terminal residue regulates fast inactivation.Arrhythmic effects of Epac-mediated ryanodine receptor activation in Langendorff-perfused murine hearts are associated with reduced conduction velocity.Mechanisms of sudden cardiac death.Regulation of the NaV1.5 cytoplasmic domain by calmodulin Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch Calpain inhibition reduces amplitude and accelerates decay of the late sodium current in ventricular myocytes from dogs with chronic heart failure Relating form and function of EF-hand calcium binding proteins.Mechanisms of a human skeletal myotonia produced by mutation in the C-terminus of NaV1.4: is Ca2+ regulation defective?Calcium and arrhythmogenesis.A sodium channel pore mutation causing Brugada syndrome Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations.Functional features of trans-differentiated hair cells mediated by Atoh1 reveals a primordial mechanism.S100 calcium binding proteins and ion channels Perturbation of sodium channel structure by an inherited Long QT Syndrome mutation.Modulation of cardiac Na(+) and Ca(2+) currents by CaM and CaMKII.Late sodium current in failing heart: friend or foe?Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences.Calmodulin and CaMKII as molecular switches for cardiac ion channels.The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles.Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heart.Pathophysiology of the cardiac late Na current and its potential as a drug target.Role of Ca(2+) in injury-induced changes in sodium current in rat skeletal muscle Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations.

P2860

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P2860

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

http://www.wikidata.org/entity/Q34300731

description

2004 nî lūn-bûn

@nan

2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年学术文章

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2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

name

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

@ast

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

@en

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

@nl

type

label

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

@ast

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

@en

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

@nl

prefLabel

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

@ast

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

@en

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

@nl

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P1433

Nature Structural & Molecular Biology

P1476

An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.

@en

P2093

Jeffrey R Balser

http://www.w3.org/2001/XMLSchema#string

Mark E Anderson

http://www.w3.org/2001/XMLSchema#string

Tammy L Wingo

http://www.w3.org/2001/XMLSchema#string

Terry P Lybrand

http://www.w3.org/2001/XMLSchema#string

Vikas N Shah

http://www.w3.org/2001/XMLSchema#string

Walter J Chazin

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P2860

A calcium sensor in the sodium channel modulates cardiac excitability

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Basic local alignment search tool

PROCHECK: a program to check the stereochemical quality of protein structures

Sequential calcium binding to the regulatory domain of calcium vector protein reveals functional asymmetry and a novel mode of structural rearrangement

A single Na(+) channel mutation causing both long-QT and Brugada syndromes

A sodium-channel mutation causes isolated cardiac conduction disease

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

A new approach to protein fold recognition

Crystal structures of the helix-loop-helix calcium-binding proteins

P2888

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219-225

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10.1038/NSMB737

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3

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11

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2004-02-22T00:00:00Z

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6602679

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14981509

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