Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. - Wikidata - wikimedia - TriplyDB

Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.

Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.

http://www.wikidata.org/entity/Q34305158

about

Increased tissue factor-initiated prothrombin activation as a result of the Arg506 --> Gln mutation in factor VLEIDEN The discovery of activated protein C resistance Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain Prothrombotic phenotype of protein Z deficiency Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.Factor Va, bound to microparticles released during platelet storage, is resistant to inactivation by activated protein C.Inhibition of thrombin formation by active site mutated (S360A) activated protein C.An engineered factor Va prevents bleeding induced by anticoagulant wt activated protein C Modeling of human factor Va inactivation by activated protein C.Cleavage at both Arg306 and Arg506 is required and sufficient for timely and efficient inactivation of factor Va by activated protein C.Molecular recognition in the protein C anticoagulant pathway.Erythrocyte-derived microparticles supporting activated protein C-mediated regulation of blood coagulation Notecarin D binds human factor V and factor Va with high affinity in the absence of membranes.Binding of calcium to anticoagulant protein S: role of the fourth EGF module The role of thrombin exosites I and II in the activation of human coagulation factor V.Phosphorylation of protein S by platelet kinases enhances its activated protein C cofactor activity.Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency.Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway.Dissociation of activated protein C functions by elimination of protein S cofactor enhancement.HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation Amino acid region 1000-1008 of factor V is a dynamic regulator for the emergence of procoagulant activity.APC resistance: biological basis and acquired influences.Down-regulation of the clotting cascade by the protein C pathway The protein C pathway in intestinal barrier function: challenging the hemostasis paradigm.Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C Pro- and anticoagulant properties of factor V in pathogenesis of thrombosis and bleeding disorders.Association of Hemostatic Gene Polymorphisms With Early-Onset Ischemic Heart Disease in Egyptian Patients.Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein S and factor V.Mapping of the factor Xa binding site on factor Va by site-directed mutagenesis Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va.Function of the activated protein C (APC) autolysis loop in activated FVIII inactivation.Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S.Protein C activation on endothelial cells by prothrombin activation products generated in situ: meizothrombin is a better protein C activator than alpha-thrombin.Regulation of platelet factor Va-dependent thrombin generation by activated protein C at the surface of collagen-adherent platelets.Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va.Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.Defining the factor Xa-binding site on factor Va by site-directed glycosylation.Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va.The risk of venous thromboembolism associated with the factor V Leiden mutation and low B-vitamin status.

P2860

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P2860

Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.

http://www.wikidata.org/entity/Q34305158

description

1995 nî lūn-bûn

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1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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1995年の論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年论文

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name

Peptide bond cleavages and los ...... aR506Q by activated protein C.

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Peptide bond cleavages and los ...... aR506Q by activated protein C.

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Peptide bond cleavages and los ...... aR506Q by activated protein C.

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type

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Peptide bond cleavages and los ...... aR506Q by activated protein C.

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Peptide bond cleavages and los ...... aR506Q by activated protein C.

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Peptide bond cleavages and los ...... aR506Q by activated protein C.

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Peptide bond cleavages and los ...... aR506Q by activated protein C.

@ast

Peptide bond cleavages and los ...... aR506Q by activated protein C.

@en

Peptide bond cleavages and los ...... aR506Q by activated protein C.

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JBC.270.36.21158

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Journal of Biological Chemistry

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Peptide bond cleavages and los ...... aR506Q by activated protein C.

@en

P2093

Nicolaes GA

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Pabinger I

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Rosing J

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Schwarz HP

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Tans G

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Thomassen MC

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Varadi K

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P2860

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C

Deficiency of protein C in congenital thrombotic disease

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Measurement of protein using bicinchoninic acid

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S

Kinetic studies of prothrombin activation: effect of factor Va and phospholipids on the formation of the enzyme-substrate complex

Mutation in blood coagulation factor V associated with resistance to activated protein C.

Familial protein S deficiency is associated with recurrent thrombosis.

Human coagluation factor V purification and thrombin-catalyzed activation

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21158-21166

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10.1074/JBC.270.36.21158

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36

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270

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Hendrik Coenraad Hemker

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15526306

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7673148

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