The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging.
about
Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathyMuscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum.Allele-specific gene silencing in two mouse models of autosomal dominant skeletal myopathy.Ca2+ release in muscle fibers expressing R4892W and G4896V type 1 ryanodine receptor disease mutantsDifferential effect of calsequestrin ablation on structure and function of fast and slow skeletal muscle fibers.Type 1 ryanodine receptor knock-in mutation causing central core disease of skeletal muscle also displays a neuronal phenotype.Sequential stages in the age-dependent gradual formation and accumulation of tubular aggregates in fast twitch muscle fibers: SERCA and calsequestrin involvement.Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damageAge-dependent uncoupling of mitochondria from Ca2⁺ release units in skeletal muscle.Novel details of calsequestrin gel conformation in situSkeletal Muscle Microalterations in Patients Carrying Malignant Hyperthermia-Related Mutations of the e-c Coupling Machinery.A chemical chaperone improves muscle function in mice with a RyR1 mutation.The disorders of the calcium release unit of skeletal muscles: what have we learned from mouse models?Editorial: The EJTM Special "Mobility in Elderly".The Ejtm Specials "The Long-Term Denervated Muscle".Dyad content is reduced in cardiac myocytes of mice with impaired calmodulin regulation of RyR2.A method for the ultrastructural preservation of tiny percutaneous needle biopsy material from skeletal muscle.Potassium dependent rescue of a myopathy with core-like structures in mouse.Design Principles of Reptilian Muscles: Calcium Cycling Strategies.Defects in Ca2+ release associated with local expression of pathological ryanodine receptors in mouse muscle fibres.Inositol trisphosphate receptor-mediated Ca2+ signalling stimulates mitochondrial function and gene expression in core myopathy patients.Clinical and genetic findings in a large cohort of patients with ryanodine receptor 1 gene-associated myopathiesRyanodine receptors
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P2860
The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The I4895T mutation in the typ ...... le that mimic premature aging.
@ast
The I4895T mutation in the typ ...... le that mimic premature aging.
@en
The I4895T mutation in the typ ...... le that mimic premature aging.
@nl
type
label
The I4895T mutation in the typ ...... le that mimic premature aging.
@ast
The I4895T mutation in the typ ...... le that mimic premature aging.
@en
The I4895T mutation in the typ ...... le that mimic premature aging.
@nl
prefLabel
The I4895T mutation in the typ ...... le that mimic premature aging.
@ast
The I4895T mutation in the typ ...... le that mimic premature aging.
@en
The I4895T mutation in the typ ...... le that mimic premature aging.
@nl
P2093
P2860
P1433
P1476
The I4895T mutation in the typ ...... le that mimic premature aging.
@en
P2093
Robert T Dirksen
Ryan E Loy
Simona Boncompagni
P2860
P304
P356
10.1111/J.1474-9726.2010.00623.X
P577
2010-10-21T00:00:00Z