Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.
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Getting Ready for the Dance: FANCJ Irons Out DNA WrinklesUpdate of the human and mouse Fanconi anemia genesDisease-causing missense mutations in human DNA helicase disordersMolecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndromeEmerging critical roles of Fe-S clusters in DNA replication and repair.Insight into the roles of helicase motif Ia by characterizing Fanconi anemia group J protein (FANCJ) patient mutationsNovel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.Simultaneous binding to the tracking strand, displaced strand and the duplex of a DNA fork enhances unwinding by Dda helicaseMolecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemiaHelicase-inactivating mutations as a basis for dominant negative phenotypes.The phenotype of FancB-mutant mouse embryonic stem cells.Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction.DNA helicases involved in DNA repair and their roles in cancerDNA helicases associated with genetic instability, cancer, and aging.DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster.The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndromeAnalysis of BRIP1 Variants among Korean Patients with BRCA1/2 Mutation-Negative High-Risk Breast Cancer.Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management.Grip it and rip it: structural mechanisms of DNA helicase substrate binding and unwinding.FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation.Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism.FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells.On human disease-causing amino acid variants: statistical study of sequence and structural patterns.FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.BRIP1 coding variants are associated with a high risk of hepatocellular carcinoma occurrence in patients with HCV- or HBV-related liver disease.Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host.Iron-sulfur cluster biosynthesis and trafficking - impact on human disease conditions.RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.New Insights Into DNA Helicases as Druggable Targets for Cancer TherapyA minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repairDetection of G-quadruplex DNA in mammalian cells
P2860
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P2860
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.
description
2010 nî lūn-bûn
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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Fanconi anemia group J mutatio ...... tion of protein-DNA complexes.
@ast
Fanconi anemia group J mutatio ...... tion of protein-DNA complexes.
@en
Fanconi anemia group J mutatio ...... tion of protein-DNA complexes.
@nl
type
label
Fanconi anemia group J mutatio ...... tion of protein-DNA complexes.
@ast
Fanconi anemia group J mutatio ...... tion of protein-DNA complexes.
@en
Fanconi anemia group J mutatio ...... tion of protein-DNA complexes.
@nl
prefLabel
Fanconi anemia group J mutatio ...... tion of protein-DNA complexes.
@ast
Fanconi anemia group J mutatio ...... tion of protein-DNA complexes.
@en
Fanconi anemia group J mutatio ...... tion of protein-DNA complexes.
@nl
P2093
P2860
P1433
P1476
Fanconi anemia group J mutatio ...... ption of protein-DNA complexes
@en
P2093
Alexander V Mazin
Avvaru N Suhasini
Hiroyuki Kitao
Joshua A Sommers
Julianna S Deakyne
Robert M Brosh
Yuliang Wu
P2860
P304
P356
10.1182/BLOOD-2009-11-256016
P407
P577
2010-07-16T00:00:00Z