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Pore-opening mechanism in trimeric P2X receptor channels

Pore-opening mechanism in trimeric P2X receptor channels

http://www.wikidata.org/entity/Q34313783

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Molecular and functional properties of P2X receptors--recent progress and persisting challenges Ion access pathway to the transmembrane pore in P2X receptor channels Insights into the channel gating of P2X receptors from structures, dynamics and small molecules Structure and activity of the acid-sensing ion channels Size matters in activation/inhibition of ligand-gated ion channels Principles and properties of ion flow in P2X receptors Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms Molecular mechanism of ATP binding and ion channel activation in P2X receptors X-ray structures define human P2X3 receptor gating cycle and antagonist action A dual polybasic motif determines phosphoinositide binding and regulation in the P2X channel family Physical basis of apparent pore dilation of ATP-activated P2X receptor channels Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region Localization of the gate and selectivity filter of the full-length P2X7 receptor Mechanisms of ATP release and signalling in the blood vessel wall.Tightening of the ATP-binding sites induces the opening of P2X receptor channels Signal transmission within the P2X2 trimeric receptor.Neuromodulation by extracellular ATP and P2X receptors in the CNS.General rules for the arrangements and gating motions of pore-lining helices in homomeric ion channels.Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers Position and motions of the S4 helix during opening of the Shaker potassium channel.The second transmembrane domain of P2X7 contributes to dilated pore formation Functional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptor Agonist trapped in ATP-binding sites of the P2X2 receptor.Activation and regulation of purinergic P2X receptor channels Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7).Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulations Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel Subtype-specific control of P2X receptor channel signaling by ATP and Mg2+.Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels.Emerging approaches to probing ion channel structure and function.Post-translational regulation of P2X receptor channels: modulation by phospholipids Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Ectodomain movements of an ATP-gated ion channel (P2X2 receptor) probed by disulfide locking.Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor.The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels.Metal bridges illuminate transmembrane domain movements during gating of the cystic fibrosis transmembrane conductance regulator chloride channel.Direct gating of ATP-activated ion channels (P2X2 receptors) by lipophilic attachment at the outer end of the second transmembrane domain STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.The pain receptor TRPV1 displays agonist-dependent activation stoichiometry.Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor.

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P2860

Pore-opening mechanism in trimeric P2X receptor channels

http://www.wikidata.org/entity/Q34313783

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Pore-opening mechanism in trimeric P2X receptor channels

@ast

Pore-opening mechanism in trimeric P2X receptor channels

@en

Pore-opening mechanism in trimeric P2X receptor channels

@nl

type

label

Pore-opening mechanism in trimeric P2X receptor channels

@ast

Pore-opening mechanism in trimeric P2X receptor channels

@en

Pore-opening mechanism in trimeric P2X receptor channels

@nl

prefLabel

Pore-opening mechanism in trimeric P2X receptor channels

@ast

Pore-opening mechanism in trimeric P2X receptor channels

@en

Pore-opening mechanism in trimeric P2X receptor channels

@nl

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Nature Communications

P1476

Pore-opening mechanism in trimeric P2X receptor channels

@en

P2093

Kenton J Swartz

http://www.w3.org/2001/XMLSchema#string

Mufeng Li

http://www.w3.org/2001/XMLSchema#string

Shai D Silberberg

http://www.w3.org/2001/XMLSchema#string

Toshimitsu Kawate

http://www.w3.org/2001/XMLSchema#string

P2860

The voltage-gated potassium channels and their relatives

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectification

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

Structure of the KcsA channel intracellular gate in the open state

Crystal structure and mechanism of a calcium-gated potassium channel

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH

High-resolution structure of the open NaK channel

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

Structure of a tetrameric MscL in an expanded intermediate state

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44

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scholarly article

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10.1038/NCOMMS1048

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1

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2010-07-27T00:00:00Z

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47545093

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1007451590

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20975702

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2982178

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