Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. - Wikidata - wikimedia - TriplyDB

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.

http://www.wikidata.org/entity/Q34319297

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In search of low-frequency and rare variants affecting complex traits Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland 60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C Opportunities and Challenges of Genotyping Patients With Nephrotic Syndrome in the Genomic Era Identifying a novel locus for psoriatic arthritis Rare-variant association analysis: study designs and statistical tests Challenges in elucidating the genetics of diabetic retinopathy Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA).The MKK7 p.Glu116Lys Rare Variant Serves as a Predictor for Lung Cancer Risk and Prognosis in Chinese.Long Noncoding RNAs in Metabolic Syndrome Related Disorders Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS Gene-based rare allele analysis identified a risk gene of Alzheimer's disease Quality control and conduct of genome-wide association meta-analyses Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study MetaRanker 2.0: a web server for prioritization of genetic variation data The genetic architecture of type 2 diabetes Genetics of Type 2 Diabetes: the Power of Isolated Populations.Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity.Multi-ethnic analysis reveals soluble L-selectin may be post-transcriptionally regulated by 3'UTR polymorphism: the Multi-Ethnic Study of Atherosclerosis (MESA).Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.Genetics of hypertension: discoveries from the bench to human populations.Variant association tools for quality control and analysis of large-scale sequence and genotyping array data Integrative analysis of sequencing and array genotype data for discovering disease associations with rare mutations.Improved ancestry estimation for both genotyping and sequencing data using projection procrustes analysis and genotype imputation.Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.A new strategy for enhancing imputation quality of rare variants from next-generation sequencing data via combining SNP and exome chip data.Efficient Software for Multi-marker, Region-Based Analysis of GWAS Data.The Weighting is the Hardest Part: On the Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples Exome-wide association study of endometrial cancer in a multiethnic population Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.Distribution and medical impact of loss-of-function variants in the Finnish founder population.No large-effect low-frequency coding variation found for myocardial infarction Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in mouse Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism Identification of rare variants in Alzheimer's disease.

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Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.

http://www.wikidata.org/entity/Q34319297

description

2012 nî lūn-bûn

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2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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Exome array analysis identifie ...... ulin processing and secretion.

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Exome array analysis identifie ...... ulin processing and secretion.

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Nature Genetics

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Alena Stančáková

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Benjamin M Neale

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Elizabeth W Pugh

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Henna Cederberg

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Hua Ling

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Hyun Min Kang

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Ivy McMullen

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Jane M Romm

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Jeroen R Huyghe

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Kimberly F Doheny

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Population structure and eigenanalysis

GENCODE: producing a reference annotation for ENCODE

In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets

Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway

RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins

Functional dissection of Rab GTPases involved in primary cilium formation

Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity

Common variants at 30 loci contribute to polygenic dyslipidemia

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

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197-201

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10.1038/NG.2507

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2

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45

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Gonçalo Abecasis

Alena Stančáková

Johanna Kuusisto

Francis Collins

Christian Fuchsberger

Mark Joseph Daly

Heather M Stringham

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2012-12-23T00:00:00Z

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23263489

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