IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan. - Wikidata - wikimedia - TriplyDB

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan.

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan.

http://www.wikidata.org/entity/Q34319398

about

Targeting the indoleamine 2,3-dioxygenase pathway in cancer The mTOR pathway and integrating immune regulation The role of IDO in brain tumor immunotherapy Metabolic regulation of regulatory T cell development and function IDO2 in Immunomodulation and Autoimmune Disease The Novel PKCθ from Benchtop to Clinic IDO2: A Pathogenic Mediator of Inflammatory Autoimmunity Meat Intake and the Dose of Vitamin B3 - Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?The role of placental tryptophan catabolism Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment.Tryptophan-catabolizing enzymes - party of three IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis.Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors 1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis.The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists.Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors.Tryptophan-degrading enzymes in tumoral immune resistance.Indoleamine-2,3-dioxygenase (IDO) metabolic activity is detrimental for cervical cancer patient survival.Kynurenine and uric acid levels in chronic myeloid leukemia patients.Exogenous Tryptophan Promotes Cutaneous Wound Healing of Chronically Stressed Mice through Inhibition of TNF-α and IDO Activation.1-Methyl-D-tryptophan potentiates TGF-β-induced epithelial-mesenchymal transition in T24 human bladder cancer cells.Salmonella overcomes tumor immune tolerance by inhibition of tumor indoleamine 2, 3-dioxygenase 1 expression Indoleamine 2,3-dioxygenase activity and clinical outcome following induction chemotherapy and concurrent chemoradiation in Stage III non-small cell lung cancer.IDO2 Modulates T Cell-Dependent Autoimmune Responses through a B Cell-Intrinsic Mechanism.Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.A phase I study of indoximod in patients with advanced malignancies Neutrophils are Essential in Short Hairpin RNA of Indoleamine 2,3- Dioxygenase Mediated-antitumor Efficiency Mesenchymal stromal cells as vehicles of tetravalent bispecific Tandab (CD3/CD19) for the treatment of B cell lymphoma combined with IDO pathway inhibitor D-1-methyl-tryptophan.Chlamydia-host cell interaction not only from a bird's eye view: some lessons from Chlamydia psittaci.Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease.Metabolic control of tumour progression and antitumour immunity Immunostimulatory activity of lifespan-extending agents.Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer.Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy.High immunosuppressive burden in cancer patients: a major hurdle for cancer immunotherapy.Suppression of Th1 differentiation by tryptophan supplementation in vivo.Metabolic regulation of immune responses: therapeutic opportunities.The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.

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P2860

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan.

http://www.wikidata.org/entity/Q34319398

description

2012 nî lūn-bûn

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2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

IDO inhibits a tryptophan suff ...... eted by D-1-methyl-tryptophan.

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IDO inhibits a tryptophan suff ...... eted by D-1-methyl-tryptophan.

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IDO inhibits a tryptophan suff ...... eted by D-1-methyl-tryptophan.

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IDO inhibits a tryptophan suff ...... eted by D-1-methyl-tryptophan.

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IDO inhibits a tryptophan suff ...... eted by D-1-methyl-tryptophan.

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IDO inhibits a tryptophan suff ...... eted by D-1-methyl-tryptophan.

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IDO inhibits a tryptophan suff ...... eted by D-1-methyl-tryptophan.

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IDO inhibits a tryptophan suff ...... eted by D-1-methyl-tryptophan.

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IDO inhibits a tryptophan suff ...... geted by D-1-methyl-tryptophan

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Charles J Link

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George C Prendergast

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James B Duhadaway

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Mario R Mautino

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Nicholas N Vahanian

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Richard Metz

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Sonja Rust

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P2860

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan

The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Calreticulin exposure dictates the immunogenicity of cancer cell death

Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses

Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction

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1460-1468

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scholarly article

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10.4161/ONCI.21716

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9

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1

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233977924

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23264892

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3525601

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