Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. - Wikidata - wikimedia - TriplyDB

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors.

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors.

http://www.wikidata.org/entity/Q34323825

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Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal Wnt Signaling in Cancer Stem Cell Biology Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer Advances in targeted and immunobased therapies for colorectal cancer in the genomic era Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment Therapies targeting cancer stem cells: Current trends and future challenges Development of anticancer agents targeting the Wnt/β-catenin signaling Therapy for BRAFi-Resistant Melanomas: Is WNT5A the Answer?Targeting the Wnt pathways for therapies Wnt signaling pathway in non-small cell lung cancer Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance Glioblastoma cancer stem cells: Biomarker and therapeutic advances Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28 Can nanomedicines kill cancer stem cells?Patient-derived xenograft models of breast cancer and their predictive power The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma.In vitro models of cancer stem cells and clinical applications Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma.Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells.Emergence of TNIK inhibitors in cancer therapeutics.WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors.Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy.The CREB-binding protein inhibitor ICG-001 suppresses pancreatic cancer growth.Oral epithelial stem cells - implications in normal development and cancer metastasis.Updating the Wnt pathways.Great challenges in molecular medicine: toward personalized medicine.Signalling pathways in endometrial cancer Wnt-5a ligand modulates mitochondrial fission-fusion in rat hippocampal neurons Wnt pathway activity in breast cancer sub-types and stem-like cells Triple-negative breast cancer: new perspectives for targeted therapies.Targeting cancer stem cells in solid tumors by vitamin D.Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression Functional inhibition of β-catenin-mediated Wnt signaling by intracellular VHH antibodies Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.Structural dynamics and inhibitor searching for Wnt-4 protein using comparative computational studies.Can we safely target the WNT pathway?

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Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors.

http://www.wikidata.org/entity/Q34323825

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2012 nî lūn-bûn

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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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Proceedings of the National Academy of Sciences of the United States of America

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Wnt pathway inhibition via the ...... umorigenicity of human tumors.

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Aaron Sato

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Andrew Lam

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Ann M Kapoun

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Aurélie Chaudhari

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Austin Gurney

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Cecile Chartier

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Christopher J Bond

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Fumiko Axelrod

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Hoang Tran

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In-Kyung Park

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P2860

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells

Wnt/beta-catenin signaling: components, mechanisms, and diseases

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

Phenotypic characterization of human colorectal cancer stem cells

Prospective identification of tumorigenic breast cancer cells

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