A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
about
Therapeutic potential of TAS-102 in the treatment of gastrointestinal malignanciesPhase I study of TAS-102 treatment in Japanese patients with advanced solid tumours.Phase 1 study of oral TAS-102 in patients with refractory metastatic colorectal cancer.New active drugs for the treatment of advanced colorectal cancer.Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells.The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cellsHuman mass balance study of TAS-102 using (14)C analyzed by accelerator mass spectrometryThe antibodies against 5-bromo-2'-deoxyuridine specifically recognize trifluridine incorporated into DNA.TAS-102: a novel antimetabolite for the 21st century.Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer.Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, together with bevacizumab, cetuximab, or panitumumab on human colorectal cancer xenografts.Panitumumab interaction with TAS-102 leads to combinational anticancer effects via blocking of EGFR-mediated tumor response to trifluridine.MicroRNA profiles involved in trifluridine resistance.Simple and rapid enzymatic method for the synthesis of single-strand oligonucleotides containing trifluorothymidine.Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine, tipiracil and the novel triple angiokinase inhibitor nintedanib, on human colorectal cancer xenografts.Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks.Synergistic anticancer activity of a novel oral chemotherapeutic agent containing trifluridine and tipiracil in combination with anti-PD-1 blockade in microsatellite stable-type murine colorectal cancer cells.DNA replication stress and cancer chemotherapy.Radiosynthesis of the anticancer nucleoside analogue Trifluridine using an automated 18F-trifluoromethylation procedure.
P2860
Q26777679-5D5DCF19-2314-486A-8E91-6DC4FCAACD93Q33401982-0A04ACA5-F737-474A-A60A-C043DA03CCA8Q36181265-D9250B9B-18B8-46AC-8734-79BBEA08634BQ36405969-2A57DA98-D091-4248-A677-7992F239E679Q36609769-FBBD3AE8-46CD-47EB-B5A1-D1C9594811A9Q36610507-7BB681A3-17FA-483A-B53B-AD135F107BF9Q36619557-20A37A51-9CD8-412E-ABD4-FC5B0F85C1E5Q36860056-FE1C4B6C-B1F3-4300-A2E1-B3AF939EFEF7Q38652269-D3BF9FF4-B4AA-4857-A8B0-2ECF3FCB71ECQ38697671-F39E07CE-D23D-4155-86EA-B74E2F1ABB3DQ38894690-9E3BC5A7-0995-4F56-AD5E-F1D829293D77Q41195691-074DE735-9B8E-4841-B8A8-22F7AAE885ECQ41593018-94520963-23B4-4511-A1D5-4E78B9B47470Q42011930-B4DDA622-D0F5-44AC-B454-B66172636C07Q42367389-D969BE38-DC20-47CD-B284-71B70149A939Q43080247-CE953D0B-0B66-4FC9-840F-DCA29669EB4FQ47145915-D8A3F477-A1E7-41F7-92E4-2520284AE4A1Q48247320-89AB96B7-97BE-4AA5-81F7-1099CCCAF9EAQ52599217-5F6FA950-3922-4944-A759-FCD6A0F7B263
P2860
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A novel combination antimetabo ...... ving FTD incorporation in DNA.
@ast
A novel combination antimetabo ...... ving FTD incorporation in DNA.
@en
A novel combination antimetabo ...... ving FTD incorporation in DNA.
@nl
type
label
A novel combination antimetabo ...... ving FTD incorporation in DNA.
@ast
A novel combination antimetabo ...... ving FTD incorporation in DNA.
@en
A novel combination antimetabo ...... ving FTD incorporation in DNA.
@nl
prefLabel
A novel combination antimetabo ...... ving FTD incorporation in DNA.
@ast
A novel combination antimetabo ...... ving FTD incorporation in DNA.
@en
A novel combination antimetabo ...... ving FTD incorporation in DNA.
@nl
P2093
P1476
A novel combination antimetabo ...... ving FTD incorporation in DNA.
@en
P2093
Hideyuki Ohshimo
Masahiro Yamaguchi
Masakazu Fukushima
Norihiko Suzuki
Tomohiro Emura
P304
P577
2004-09-01T00:00:00Z