Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects.
about
Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of actionKappa opioid antagonists: past successes and future prospectsDynorphin, stress, and depressionNeurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodentsKappa-opioid ligands in the study and treatment of mood disordersPharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependenceκ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addictionRole of kappa-opioid receptors in stress and anxiety-related behavior.Drug withdrawal conceptualized as a stressor.Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and RewardNeurobiology of aversive states.Kappa Opioids, Salvinorin A and Major Depressive DisorderEffect of chronic ethanol on enkephalin in the hypothalamus and extra-hypothalamic areasCRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behaviorCorticotropin-releasing factor (CRF)-induced disruption of attention in rats is blocked by the κ-opioid receptor antagonist JDTic.Kappa-opioid receptor signaling in the striatum as a potential modulator of dopamine transmission in cocaine dependenceThe locus coeruleus: A key nucleus where stress and opioids intersect to mediate vulnerability to opiate abuse.Analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activityMolecular and genetic substrates linking stress and addiction30 years of dynorphins--new insights on their functions in neuropsychiatric diseasesActivation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.Presynaptic inhibition of diverse afferents to the locus ceruleus by kappa-opiate receptors: a novel mechanism for regulating the central norepinephrine systemDeficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress.Upregulation of gene expression in reward-modulatory striatal opioid systems by sleep loss.Peptide kappa opioid receptor ligands: potential for drug development.Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization.Antidepressant-like effects of kappa-opioid receptor antagonists in Wistar Kyoto rats.Synergistic antidepressant-like effects between a kappa opioid antagonist (LY2444296) and a delta opioid agonist (ADL5859) in the mouse forced swim test.The role of kappa opioid receptors in stress-induced reinstatement of alcohol seeking in ratsEffect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse.Role of the kappa-opioid receptor system in stress-induced reinstatement of nicotine seeking in rats.The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuseNeurobiology of dysregulated motivational systems in drug addiction.Evaluation of the agonist PET radioligand [¹¹C]GR103545 to image kappa opioid receptor in humans: kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242.The role of kappa-opioid receptor activation in mediating antinociception and addiction.Agonist-induced internalization of κ-opioid receptors in noradrenergic neurons of the rat locus coeruleusSalvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse.An Improved Antagonist Radiotracer for the κ-Opioid Receptor: Synthesis and Characterization of (11)C-LY2459989.Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in miceEffects of a post-shock injection of the kappa opioid receptor antagonist norbinaltorphimine (norBNI) on fear and anxiety in rats.
P2860
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P2860
Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects.
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Stress increases dynorphin imm ...... s antidepressant-like effects.
@ast
Stress increases dynorphin imm ...... s antidepressant-like effects.
@en
Stress increases dynorphin imm ...... s antidepressant-like effects.
@nl
type
label
Stress increases dynorphin imm ...... s antidepressant-like effects.
@ast
Stress increases dynorphin imm ...... s antidepressant-like effects.
@en
Stress increases dynorphin imm ...... s antidepressant-like effects.
@nl
prefLabel
Stress increases dynorphin imm ...... s antidepressant-like effects.
@ast
Stress increases dynorphin imm ...... s antidepressant-like effects.
@en
Stress increases dynorphin imm ...... s antidepressant-like effects.
@nl
P2093
P1476
Stress increases dynorphin imm ...... s antidepressant-like effects.
@en
P2093
Gen-I Hazama
Hisahito Ishida
Masaaki Iwata
Ronald S Duman
Ryuzou Kawahara
Yukihiko Shirayama
P304
P356
10.1111/J.1471-4159.2004.02589.X
P407
P577
2004-09-01T00:00:00Z