Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence.
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Connecting the study of wild influenza with the potential for pandemic diseaseAssessment of the internal genes of influenza A (H7N9) virus contributing to high pathogenicity in miceH9N2 influenza virus in China: a cause of concernMolecular determinants of influenza virus pathogenesis in mice.Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity.Replication and transcription activities of ribonucleoprotein complexes reconstituted from avian H5N1, H1N1pdm09 and H3N2 influenza A virusesGenetic and antigenic evolution of H9N2 avian influenza viruses circulating in Egypt between 2011 and 2013.A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus.Global and quantitative proteomic analysis of dogs infected by avian-like H3N2 canine influenza virus.Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China.Amino acid 316 of hemagglutinin and the neuraminidase stalk length influence virulence of H9N2 influenza virus in chickens and mice.Rapid emergence of a virulent PB2 E627K variant during adaptation of highly pathogenic avian influenza H7N7 virus to miceFecal influenza in mammals: selection of novel variants.Amino acid substitutions involved in the adaptation of a novel highly pathogenic H5N2 avian influenza virus in mice.Two Genetically Similar H9N2 Influenza A Viruses Show Different Pathogenicity in Mice.NEDDylation of PB2 Reduces Its Stability and Blocks the Replication of Influenza A VirusComparison of biological characteristics of H9N2 avian influenza viruses isolated from different hosts.Novel reassortant H9N2 viruses in pigeons and evidence for antigenic diversity of H9N2 viruses isolated from quails in Egypt.Isolation and full genome characterization of avian influenza subtype H9N2 from poultry respiratory disease outbreak in Egypt.The significance of avian influenza virus mouse-adaptation and its application in characterizing the efficacy of new vaccines and therapeutic agents.Characterization of reassortant H1-subtype avian influenza viruses isolated from poultry in Zhejiang Province in China from 2013 to 2015.Cytokine expression in three chicken host systems infected with H9N2 influenza viruses with different pathogenicities.Isolation and molecular characterization of reassortant H11N3 subtype avian influenza viruses isolated from domestic ducks in Zhejiang Province in China.Multiple amino acid substitutions involved in the adaptation of avian-origin influenza A (H10N7) virus in mice.Rapid emergence of a PB2-E627K substitution confers a virulent phenotype to an H9N2 avian influenza virus during adoption in mice.Rapid production of a H₉ N₂ influenza vaccine from MDCK cells for protecting chicken against influenza virus infection.Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.Analysis of the phylogeny of Chinese H9N2 avian influenza viruses and their pathogenicity in mice.H9N2 influenza virus isolated from minks has enhanced virulence in mice.Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.
P2860
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P2860
Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
name
Mouse-adapted H9N2 influenza A ...... e critical for high virulence.
@ast
Mouse-adapted H9N2 influenza A ...... e critical for high virulence.
@en
Mouse-adapted H9N2 influenza A ...... e critical for high virulence.
@nl
type
label
Mouse-adapted H9N2 influenza A ...... e critical for high virulence.
@ast
Mouse-adapted H9N2 influenza A ...... e critical for high virulence.
@en
Mouse-adapted H9N2 influenza A ...... e critical for high virulence.
@nl
prefLabel
Mouse-adapted H9N2 influenza A ...... e critical for high virulence.
@ast
Mouse-adapted H9N2 influenza A ...... e critical for high virulence.
@en
Mouse-adapted H9N2 influenza A ...... e critical for high virulence.
@nl
P2093
P2860
P1433
P1476
Mouse-adapted H9N2 influenza A ...... e critical for high virulence.
@en
P2093
Earl G Brown
Hanchun Yang
Jingjing Wang
Jinhua Liu
Yipeng Sun
Yuanyuan Tan
P2860
P304
P356
10.1371/JOURNAL.PONE.0040752
P407
P577
2012-07-10T00:00:00Z