Correlation between the onset age of Huntington's disease and length of the trinucleotide repeat in IT-15.
about
Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtinA human HAP1 homologue. Cloning, expression, and interaction with huntingtinHuntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthaseThe Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesisA census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prionsTransgenic models of Huntington's diseaseTransgenic animal models for study of the pathogenesis of Huntington's disease and therapyThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyMutant huntingtin gene-dose impacts on aggregate deposition, DARPP32 expression and neuroinflammation in HdhQ150 miceDisease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolismContinuous and periodic expansion of CAG repeats in Huntington's disease R6/1 miceExpression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cellsAggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assaysCharacterization of a large group of individuals with huntington disease and their relatives enrolled in the COHORT study.Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.Risk-taking and pathological gambling behavior in Huntington's diseaseGenetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesis.Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease.Motor onset and diagnosis in Huntington disease using the diagnostic confidence level.Pathogenesis of inclusion bodies in (CAG)n/Qn-expansion diseases with special reference to the role of tissue transglutaminase and to selective vulnerability.Trinucleotide repeat length and progression of illness in Huntington's disease.Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genesAnalysis of triplet repeats in the huntingtin gene in Japanese families affected with Huntington's disease.Polyglutamine pathogenesis.QEEG Measures in Huntington's Disease: A Pilot Study.Motor-Language Coupling in Huntington's Disease Families.Huntington's disease: pathogenesis, diagnosis and treatmentOf mice and men: solving the molecular mysteries of Huntington's disease.An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors.Genetic analysis of polymorphisms in the kalirin gene for association with age-at-onset in European Huntington disease patients.Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment.CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches.The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients.Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease.Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.Indexing disease progression at study entry with individuals at-risk for Huntington diseaseThe likelihood of being affected with Huntington disease by a particular age, for a specific CAG sizeStriatal volume contributes to the prediction of onset of Huntington disease in incident cases.Anticipation and instability of IT-15 (CAG)n repeats in parent-offspring pairs with Huntington disease.Sex-dependent mechanisms for expansions and contractions of the CAG repeat on affected Huntington disease chromosomes.
P2860
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P2860
Correlation between the onset age of Huntington's disease and length of the trinucleotide repeat in IT-15.
description
1993 nî lūn-bûn
@nan
1993 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Correlation between the onset ...... trinucleotide repeat in IT-15.
@ast
Correlation between the onset ...... trinucleotide repeat in IT-15.
@en
Correlation between the onset ...... trinucleotide repeat in IT-15.
@nl
type
label
Correlation between the onset ...... trinucleotide repeat in IT-15.
@ast
Correlation between the onset ...... trinucleotide repeat in IT-15.
@en
Correlation between the onset ...... trinucleotide repeat in IT-15.
@nl
prefLabel
Correlation between the onset ...... trinucleotide repeat in IT-15.
@ast
Correlation between the onset ...... trinucleotide repeat in IT-15.
@en
Correlation between the onset ...... trinucleotide repeat in IT-15.
@nl
P2093
P356
P1476
Correlation between the onset ...... trinucleotide repeat in IT-15.
@en
P2093
P304
P356
10.1093/HMG/2.10.1547
P577
1993-10-01T00:00:00Z