Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
about
The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and functionRepression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcriptionRemodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and agingFrequent overexpression of HMGA1 and 2 in gastroenteropancreatic neuroendocrine tumours and its relationship to let-7 downregulationDisrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationLet-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinomaOverexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomasTranscriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic miceHMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathwayDeep sequencing of chicken microRNAs.Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasmsHMGA1 down-regulation is crucial for chromatin composition and a gene expression profile permitting myogenic differentiationDerepression of HMGA2 via removal of ZBRK1/BRCA1/CtIP complex enhances mammary tumorigenesis.Generation and characterisation of a canine EGFP-HMGA2 prostate cancer in vitro model.The nucleosomal binding protein NSBP1 is highly expressed in the placenta and modulates the expression of differentiation markers in placental Rcho-1 cells.Keratin 8 expression in colon cancer associates with low faecal butyrate levels.SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome.Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers.3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice.Transcriptional regulation of the HMGA1 gene by octamer-binding proteins Oct-1 and Oct-2.A novel mechanism of post-translational modulation of HMGA functions by the histone chaperone nucleophosmin.Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.Regulation of let-7 and its target oncogenes (Review)Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA RepairHMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts.The dynamics of HMG protein-chromatin interactions in living cells.Molecular deregulation induced by silencing of the high mobility group protein A2 gene in retinoblastoma cells.A novel HMGA1-CCNE2-YAP axis regulates breast cancer aggressiveness.Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomasHeat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells.Cell cycle-dependent binding of HMGN proteins to chromatin.HMG chromosomal proteins in development and disease.Chromosomal protein HMGN1 enhances the heat shock-induced remodeling of Hsp70 chromatinHomeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinityRoles of microRNAs and their targets in cancer.High mobility group proteins and their post-translational modifications.HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cellsHMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness.
P2860
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P2860
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
@ast
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
@en
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
@nl
type
label
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
@ast
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
@en
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
@nl
prefLabel
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
@ast
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
@en
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
@nl
P2093
P2860
P1433
P1476
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer.
@en
P2093
Alessandra Rustighi
Guidalberto Manfioletti
Julie Di Bernardo
Michela A Tessari
Sandro Altamura
Vincenzo Giancotti
P2860
P356
10.1016/J.FEBSLET.2004.08.013
P407
P577
2004-09-01T00:00:00Z