Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle
about
Altered hypothalamic protein expression in a rat model of Huntington's diseaseBeta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residuesLegal but lethal: functional protein aggregation at the verge of toxicityThe role of Akt/FoxO3a in the protective effect of venlafaxine against corticosterone-induced cell death in PC12 cellsDynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo.Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules.Cellular strategies of protein quality control.Huntingtin fragments and SOD1 mutants form soluble oligomers in the cellFragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon agingThe novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans.Neurodegenerative Diseases: Multifactorial Conformational Diseases and Their Therapeutic InterventionsA screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.Suppression of protein aggregation by chaperone modification of high molecular weight complexesThe emerging role of the first 17 amino acids of huntingtin in Huntington's diseaseConformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect.Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease modelsAggregation formation in the polyglutamine diseases: protection at a cost?E. coli chaperones DnaK, Hsp33 and Spy inhibit bacterial functional amyloid assembly.A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70.DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios.Amyloid in neurodegenerative diseases: friend or foe?The role of amyloidogenic protein oligomerization in neurodegenerative disease.Opportunities and challenges for molecular chaperone modulation to treat protein-conformational brain diseasesAssociation of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door?The unfolded protein response and its potential role in Huntington's disease elucidated by a systems biology approach.Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosisPrefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation.Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers.
P2860
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P2860
Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Hsp70 and Hsp40 functionally i ...... c ATP-dependent reaction cycle
@ast
Hsp70 and Hsp40 functionally i ...... c ATP-dependent reaction cycle
@en
Hsp70 and Hsp40 functionally i ...... c ATP-dependent reaction cycle
@nl
type
label
Hsp70 and Hsp40 functionally i ...... c ATP-dependent reaction cycle
@ast
Hsp70 and Hsp40 functionally i ...... c ATP-dependent reaction cycle
@en
Hsp70 and Hsp40 functionally i ...... c ATP-dependent reaction cycle
@nl
prefLabel
Hsp70 and Hsp40 functionally i ...... c ATP-dependent reaction cycle
@ast
Hsp70 and Hsp40 functionally i ...... c ATP-dependent reaction cycle
@en
Hsp70 and Hsp40 functionally i ...... c ATP-dependent reaction cycle
@nl
P2093
P2860
P356
P1476
Hsp70 and Hsp40 functionally i ...... c ATP-dependent reaction cycle
@en
P2093
Charles Glabe
Cheping Ng
Emily J Mitchell
Gregor P Lotz
Justin Legleiter
Leslie M Thompson
Paul J Muchowski
Rebecca Aron
Shao-Yi Huang
P2860
P304
38183-38193
P356
10.1074/JBC.M110.160218
P407
P577
2010-09-23T00:00:00Z