The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation. - Wikidata - wikimedia - TriplyDB

The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation.

The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation.

http://www.wikidata.org/entity/Q34355585

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The regulation of hematopoietic stem cell populations A Comparative Analysis of Genetic and Epigenetic Events of Breast and Ovarian Cancer Related to Tumorigenesis The insights of Let-7 miRNAs in oncogenesis and stem cell potency MicroRNA Regulation of Human Breast Cancer Stem Cells Functions of TET Proteins in Hematopoietic Transformation Mechanism and function of oxidative reversal of DNA and RNA methylation The TET2 interactors and their links to hematological malignancies The Role of microRNAs in Stemness of Cancer Stem Cells Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer miRNA dysregulation in cancer: towards a mechanistic understanding Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis Causes of genome instability: the effect of low dose chemical exposures in modern society Myelodysplastic syndromes: Contemporary review and how we treat.TET2 and MEG3 promoter methylation is associated with acute myeloid leukemia in a Hainan population.Modulation of microRNA expression in human lung cancer cells by the G9a histone methyltransferase inhibitor BIX01294.Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets.miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia MicroRNA-22 suppresses the growth, migration and invasion of colorectal cancer cells through a Sp1 negative feedback loop.Metabolic requirements for the maintenance of self-renewing stem cells.miR-22 in cardiac remodeling and disease Large-scale modeling of condition-specific gene regulatory networks by information integration and inference.How I treat smoldering multiple myeloma.TET proteins and the control of cytosine demethylation in cancer.Identification of let-7a-2-3p or/and miR-188-5p as prognostic biomarkers in cytogenetically normal acute myeloid leukemia Feedback signals in myelodysplastic syndromes: increased self-renewal of the malignant clone suppresses normal hematopoiesis.MiR-29b replacement inhibits proteasomes and disrupts aggresome+autophagosome formation to enhance the antimyeloma benefit of bortezomib.Global epigenetic regulation of microRNAs in multiple myeloma.MiRNA mimic screen for improved expression of functional neurotensin receptor from HEK293 cells The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis.The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia.The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema TET proteins and 5-methylcytosine oxidation in hematological cancers The Janus-faced Nature of miR-22 in Hematopoiesis: Is It an Oncogenic Tumor Suppressor or Rather a Tumor-Suppressive Oncogene?Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk MicroRNA Mechanisms of Action: What have We Learned from Mice?MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail.Acute loss of TET function results in aggressive myeloid cancer in mice.DNA methylation and hydroxymethylation in hematologic differentiation and transformation.Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis.

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P2860

The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation.

http://www.wikidata.org/entity/Q34355585

description

2013 nî lūn-bûn

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2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2013 թվականի հուլիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

The oncogenic microRNA miR-22 ...... lf-renewal and transformation.

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The oncogenic microRNA miR-22 ...... lf-renewal and transformation.

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The oncogenic microRNA miR-22 ...... lf-renewal and transformation.

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The oncogenic microRNA miR-22 ...... lf-renewal and transformation.

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The oncogenic microRNA miR-22 ...... lf-renewal and transformation.

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The oncogenic microRNA miR-22 ...... lf-renewal and transformation.

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The oncogenic microRNA miR-22 ...... lf-renewal and transformation.

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The oncogenic microRNA miR-22 ...... lf-renewal and transformation.

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The oncogenic microRNA miR-22 ...... lf-renewal and transformation.

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J.STEM.2013.06.003

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The oncogenic microRNA miR-22 ...... lf-renewal and transformation.

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David E Avigan

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Kaitlyn Webster

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Katia Manova-Todorova

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Keisuke Ito

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Lev Kats

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Mojca Jongen-Lavrencic

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Ruud Delwel

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Su Jung Song

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Su Ming Sun

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Ugo Ala

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P2860

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

miRBase: microRNA sequences, targets and gene nomenclature

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

The microRNA.org resource: targets and expression

TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).

MicroRNAs modulate hematopoietic lineage differentiation

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

MicroRNA signatures in human cancers

MicroRNAs: genomics, biogenesis, mechanism, and function

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10.1016/J.STEM.2013.06.003

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1

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Pier Paolo Pandolfi

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