about
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosisMyosin VI is a mediator of the p53-dependent cell survival pathway.T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion.How are the cellular functions of myosin VI regulated within the cell?Reaching out for signals: filopodia sense EGF and respond by directed retrograde transport of activated receptorsMyosins as fundamental components during tumorigenesis: diverse and indispensableRegulation of actin nucleation and autophagosome formationMyosins, Actin and AutophagyActin age orchestrates myosin-5 and myosin-6 run lengthsCalcium can mobilize and activate myosin-VIPrecise positioning of myosin VI on endocytic vesicles in vivoMyosin VI Dimerization Triggers an Unfolding of a Three-Helix Bundle in Order to Extend Its ReachAdaptive evolution of the myo6 gene in old world fruit bats (family: pteropodidae)Lever-arm mechanics of processive myosinsThe effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss.The power stroke of myosin VI and the basis of reverse directionality.Myosin VI is required for targeted membrane transport during cytokinesis.F-actin-based extensions of the head cyst cell adhere to the maturing spermatids to maintain them in a tight bundle and prevent their premature release in Drosophila testis.Unconventional myosin traffic in cells reveals a selective actin cytoskeleton.The structure of the myosin VI motor reveals the mechanism of directionality reversalDifferential expression of unconventional myosins in apoptotic and regenerating chick hair cells confirms two regeneration mechanisms.Aminoglycoside-induced phosphatidylserine externalization in sensory hair cells is regionally restricted, rapid, and reversible.Impairment of protein trafficking upon overexpression and mutation of optineurin.Reverse conformational changes of the light chain-binding domain of myosin V and VI processive motor heads during and after hydrolysis of ATP by small-angle X-ray solution scatteringGipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear.Combination of NMR spectroscopy and X-ray crystallography offers unique advantages for elucidation of the structural basis of protein complex assembly.Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine.Myosin VI is differentially regulated by DNA damage in p53- and cell type-dependent mannersNon-muscle myosins in tumor progression, cancer cell invasion, and metastasis.Probing intracellular motor protein activity using an inducible cargo trafficking assay.Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins.New insights into myosin evolution and classificationFlexible light-chain and helical structure of F-actin explain the movement and step size of myosin-VI.Myosin VI deafness mutation prevents the initiation of processive runs on actinStudies of optineurin, a glaucoma gene: Golgi fragmentation and cell death from overexpression of wild-type and mutant optineurin in two ocular cell types.The unique insert at the end of the myosin VI motor is the sole determinant of directionality.A novel role of myosin VI in human prostate cancerMyosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine.Myosins: tails (and heads) of functional diversity.Altered renal proximal tubular endocytosis and histology in mice lacking myosin-VI.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Myosin VI: cellular functions and motor properties.
@ast
Myosin VI: cellular functions and motor properties.
@en
Myosin VI: cellular functions and motor properties.
@nl
type
label
Myosin VI: cellular functions and motor properties.
@ast
Myosin VI: cellular functions and motor properties.
@en
Myosin VI: cellular functions and motor properties.
@nl
prefLabel
Myosin VI: cellular functions and motor properties.
@ast
Myosin VI: cellular functions and motor properties.
@en
Myosin VI: cellular functions and motor properties.
@nl
P2093
P1476
Myosin VI: cellular functions and motor properties.
@en
P2093
Folma Buss
Giulietta Spudich
John Kendrick-Jones
P304
P356
10.1146/ANNUREV.CELLBIO.20.012103.094243
P577
2004-01-01T00:00:00Z