Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.
about
A structural biology perspective on NMDA receptor pharmacology and functionNMDA receptor modulators: an updated patent review (2013-2014)Beyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.Emerging structural insights into the function of ionotropic glutamate receptors.An Integrated Approach for Screening and Identification of Positive Allosteric Modulators of N-Methyl-D-Aspartate Receptors.Cooperative Dynamics of Intact AMPA and NMDA Glutamate Receptors: Similarities and Subfamily-Specific Differences.Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target.Novel PAMs Targeting NMDAR GluN2A Subunit.GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.The bioactive protein-ligand conformation of GluN2C-selective positive allosteric modulators bound to the NMDA receptor.A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.Selective Cell-Surface Expression of Triheteromeric NMDA Receptors.NMDA Receptors in the Central Nervous System.Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site.An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups.How does binding of agonist ligands control intrinsic molecular dynamics in human NMDA receptors?A structurally derived model of subunit-dependent NMDA receptor function
P2860
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P2860
Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Structural determinants and me ...... positive allosteric modulator.
@ast
Structural determinants and me ...... positive allosteric modulator.
@en
Structural determinants and me ...... positive allosteric modulator.
@nl
type
label
Structural determinants and me ...... positive allosteric modulator.
@ast
Structural determinants and me ...... positive allosteric modulator.
@en
Structural determinants and me ...... positive allosteric modulator.
@nl
prefLabel
Structural determinants and me ...... positive allosteric modulator.
@ast
Structural determinants and me ...... positive allosteric modulator.
@en
Structural determinants and me ...... positive allosteric modulator.
@nl
P2093
P2860
P356
P1476
Structural determinants and me ...... positive allosteric modulator
@en
P2093
Alpa Khatri
Dennis C Liotta
Erkan Karakas
Hiro Furukawa
James P Snyder
Pieter B Burger
Sommer Zimmerman
Stephen F Traynelis
P2860
P304
P356
10.1124/MOL.114.094516
P577
2014-09-09T00:00:00Z