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DNA polymerases and somatic hypermutation of immunoglobulin genes

DNA polymerases and somatic hypermutation of immunoglobulin genes

http://www.wikidata.org/entity/Q34360690

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Promiscuous DNA synthesis by human DNA polymerase θ Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies Role of Pseudomonas aeruginosa dinB-encoded DNA polymerase IV in mutagenesis.Ectopic expression of AID in a non-B cell line triggers A:T and G:C point mutations in non-replicating episomal vectors.Optimization of DNA polymerase mutation rates during bacterial evolution.Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks Adaptive mutation in Saccharomyces cerevisiae.Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination DNA repair in antibody somatic hypermutation.DNA polymerase POLQ and cellular defense against DNA damage.Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity.Multiple functions of DNA polymerases.Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.DNA replication to aid somatic hypermutation Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection.REV1 and DNA polymerase zeta in DNA interstrand crosslink repair.A role for DNA polymerase θ in the timing of DNA replication.Translesion DNA polymerases in eukaryotes: what makes them tick?Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken.Gene Conversion-Like Events in the Diversification of Human Rearranged IGHV3-23*01 Gene Sequences.Hypermutation at A/T sites during G.U mismatch repair in vitro by human B-cell lysates.Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol.

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DNA polymerases and somatic hypermutation of immunoglobulin genes

http://www.wikidata.org/entity/Q34360690

description

2005 nî lūn-bûn

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2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

@zh-hk

2005年論文

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2005年論文

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2005年论文

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name

DNA polymerases and somatic hypermutation of immunoglobulin genes

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DNA polymerases and somatic hypermutation of immunoglobulin genes

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DNA polymerases and somatic hypermutation of immunoglobulin genes

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type

label

DNA polymerases and somatic hypermutation of immunoglobulin genes

@ast

DNA polymerases and somatic hypermutation of immunoglobulin genes

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DNA polymerases and somatic hypermutation of immunoglobulin genes

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prefLabel

DNA polymerases and somatic hypermutation of immunoglobulin genes

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DNA polymerases and somatic hypermutation of immunoglobulin genes

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DNA polymerases and somatic hypermutation of immunoglobulin genes

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DNA polymerases and somatic hypermutation of immunoglobulin genes

@en

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Mineaki Seki

http://www.w3.org/2001/XMLSchema#string

Patricia J Gearhart

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P2860

hRAD30 mutations in the variant form of xeroderma pigmentosum

The human REV1 gene codes for a DNA template-dependent dCMP transferase

Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7

POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells

A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

High-efficiency bypass of DNA damage by human DNA polymerase Q

Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa

poliota, a remarkably error-prone human DNA polymerase

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1143-1148

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scholarly article

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10.1038/SJ.EMBOR.7400582

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12

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6

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Richard Dean Wood

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2005-12-01T00:00:00Z

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7448938

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16319960

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1369213

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