A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes.
about
HDV-like self-cleaving ribozymesRequirement of Helix P2.2 and Nucleotide G1 for Positioning the Cleavage Site and Cofactor of the glmS RibozymeCharacterization of the trans Watson-Crick GU base pair located in the catalytic core of the antigenomic HDV ribozymeA Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme ActivationMapping of accessible sites for oligonucleotide hybridization on hepatitis delta virus ribozymesImino proton NMR analysis of HDV ribozymes: nested double pseudoknot structure and Mg2+ ion-binding site close to the catalytic core in solutionComputational discovery of folded RNA domains in genomes and in vitro selected librariesRequirement for canonical base pairing in the short pseudoknot structure of genomic hepatitis delta virus ribozyme.Disparate HDV ribozyme crystal structures represent intermediates on a rugged free-energy landscape.Long-distance communication in the HDV ribozyme: insights from molecular dynamics and experimentsConformational features of topologically classified RNA secondary structuresRibozyme cleavage of a 2,5-phosphodiester linkage: mechanism and a restricted divalent metal-ion requirement.Chemical rescue, multiple ionizable groups, and general acid-base catalysis in the HDV genomic ribozyme.Ribozyme-based gene-inactivation systems require a fine comprehension of their substrate specificities; the case of delta ribozymeCharacterization of the Structure and Dynamics of the HDV Ribozyme at Different Stages Along the Reaction Path.The genomic HDV ribozyme utilizes a previously unnoticed U-turn motif to accomplish fast site-specific catalysisWild-type is the optimal sequence of the HDV ribozyme under cotranscriptional conditionsActivity of HDV ribozymes to trans-cleave HCV RNATransition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations.Secondary structure confirmation and localization of Mg2+ ions in the mammalian CPEB3 ribozyme.A host-specific function is required for ligation of a wide variety of ribozyme-processed RNAs.Modulating RNA structure and catalysis: lessons from small cleaving ribozymes.Formation of the P1.1 pseudoknot is critical for both the cleavage activity and substrate specificity of an antigenomic trans-acting hepatitis delta ribozyme.Examination of the folding pathway of the antigenomic hepatitis delta virus ribozyme reveals key interactions of the L3 loop.Gene targeting in the Gram-Positive bacterium Lactococcus lactis, using various delta ribozymes.A novel structural rearrangement of hepatitis delta virus antigenomic ribozymeWobble pairs of the HDV ribozyme play specific roles in stabilization of active site dynamics.Delta ribozyme benefits from a good stability in vitro that becomes outstanding in vivo.The interaction networks of structured RNAs.Cross-linking experiments reveal the presence of novel structural features between a hepatitis delta virus ribozyme and its substrate.Thio effects and an unconventional metal ion rescue in the genomic hepatitis delta virus ribozyme.Monitoring of an RNA multistep folding pathway by isothermal titration calorimetry.Identification of 15 candidate structured noncoding RNA motifs in fungi by comparative genomics.Site-specific modification of functional groups in genomic hepatitis delta virus (HDV) ribozyme.Long-range impact of peripheral joining elements on structure and function of the hepatitis delta virus ribozyme.Pairwise RNA secondary structure alignment with conserved stem pattern.Secondary Structure Prediction of Single Sequences Using RNAstructure.Cleavage reaction of HDV ribozymes in the presence of Mg2+ is accompanied by a conformational change
P2860
Q24611507-99A243D5-D4B8-42F5-B072-F903C0C5F2C4Q27647856-54F591B9-744B-47C4-AB55-43765591DBEFQ28480887-17D04B20-5519-4FC6-B485-A6C33EB99234Q28821468-3EFB95F2-E58D-4673-AFB5-34A84C701EF0Q30850742-2501D7E6-5E7E-4442-8B17-D6BF0C8AE759Q33559422-D649521B-8E85-44A0-AF3F-88E0EC0D946BQ33606445-6F99A79C-D327-4FD6-A119-4151E70B0CF8Q33614755-714A28AC-9940-490A-B6D0-8BE056EA5E0AQ33967967-58A15FFF-77BE-433C-921D-8080766C0551Q34091668-81DA4481-F7B8-4024-A4CD-E1C7066B8792Q34335756-DE990C13-C23A-4F37-AC9E-05502CF40642Q34362084-72564F09-CDA3-47D5-9430-373452CB9AF7Q34702891-68BB0F6F-A0FB-4211-AC6F-3B89B4C4799CQ35552101-32B1730A-6488-4D30-81FE-8E670DC6F945Q35628399-A421D0C8-9B7D-448A-A3F1-0E6A3D5D379DQ35804539-C833D9E8-1622-4961-B500-CF50802892E4Q36148295-C8145CF1-747D-498E-AAE1-D7DF8E52CBC0Q36308214-33054E2A-8CF5-4702-9032-B874F54012C5Q36592176-3B550284-3B2D-4D10-A96C-ACD0F117ECD5Q36812728-CD1BC5DF-6936-44B9-9310-C0B11FCC1BCFQ37155807-E9486D08-68A4-4565-BA33-6B6100284B00Q37589504-DC008CEE-3029-4354-9E3E-C62C67F750A8Q39747812-C258CC2B-310D-40FB-A2A1-9CA7F23B0EDFQ41500431-796BD5E5-6DAE-4E99-83DA-7F5D334400AAQ41827296-9633D7E8-E18D-4A91-8033-626AEE2FD808Q41847996-B0E813CD-E6EC-4008-A390-85BC98AEBE74Q41877122-8101BDC3-D678-4325-ADA9-6DDC29418EF5Q41946566-9D59AC02-3BB5-4A38-A9F6-811C06FD4647Q42086831-73D52814-BF1A-44AA-BA82-8BA14D8FFEECQ42249936-A36CD728-147B-4556-9335-F4A200B2353DQ42272436-CEA52230-5A2F-47E9-9A9D-BA5A97F7BE43Q42283837-86326518-BC1A-47D7-BAA2-C2275534280DQ42377413-DA4F2E56-0BCB-4BE0-84D4-E8A000E562FFQ44224700-1D8A721D-0B2A-4ABA-A887-A3FD99DF52D7Q45402932-EDB54883-379A-42F3-97BC-C61742F73D16Q47623078-4C93785B-A20B-4FC8-BC48-EE5E5EA6DBD8Q53752236-09409F59-35C2-4230-8858-43C57B0334F8Q56957099-2F7BC614-18CC-4BC8-B4D9-B4A34F712BF6
P2860
A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A nested double pseudoknot is ...... patitis delta virus ribozymes.
@ast
A nested double pseudoknot is ...... patitis delta virus ribozymes.
@en
A nested double pseudoknot is ...... patitis delta virus ribozymes.
@nl
type
label
A nested double pseudoknot is ...... patitis delta virus ribozymes.
@ast
A nested double pseudoknot is ...... patitis delta virus ribozymes.
@en
A nested double pseudoknot is ...... patitis delta virus ribozymes.
@nl
prefLabel
A nested double pseudoknot is ...... patitis delta virus ribozymes.
@ast
A nested double pseudoknot is ...... patitis delta virus ribozymes.
@en
A nested double pseudoknot is ...... patitis delta virus ribozymes.
@nl
P2093
P2860
P1433
P1476
A nested double pseudoknot is ...... patitis delta virus ribozymes.
@en
P2093
A R Ferré-D'Amaré
A T Perrotta
T S Wadkins
P2860
P304
P356
10.1017/S1355838299990209
P407
P577
1999-06-01T00:00:00Z