Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity - Wikidata - wikimedia - TriplyDB

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

http://www.wikidata.org/entity/Q34364103

about

Adaptive immunity in the liver Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium Role of Tim-3 in hepatitis B virus infection: An overview Association of HLA-alleles with the immune regulation of chronic viral infections Overcoming T cell exhaustion in infection and cancer Immune responses to HCV and other hepatitis viruses Emerging concepts in immunity to hepatitis C virus infection.Galectins and their ligands: negative regulators of anti-tumor immunity Specific CD8(+) T cell response immunotherapy for hepatocellular carcinoma and viral hepatitis Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases Intact dendritic cell pathogen-recognition receptor functions associate with chronic hepatitis C treatment-induced viral clearance Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.Genetic diversity of near genome-wide hepatitis C virus sequences during chronic infection: evidence for protein structural conservation over time.cDNA cloning, genomic structure, molecular characterization and mRNA expression analysis of the Pekin duck interleukin-10 receptor 1.Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes.Enhanced Tim3 activity improves survival after influenza infection Effect of laparoscopic splenectomy in patients with Hepatitis C and cirrhosis carrying IL28B minor genotype Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C.Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade.CD8(+) T-Cell Responses in Acute Hepatitis C Virus Infection.Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets.Protective immunity against hepatitis C: many shades of gray.RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression Tim-3 and PD-1 regulate CD8+ T cell function to maintain early pregnancy in mice.Hurdles to the Development of Effective HBV Immunotherapies and HCV Vaccines Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation.Regulation of T cell responses by the receptor molecule Tim-3.Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory molecules Enhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum.Immune control and failure in HCV infection--tipping the balance.Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells.Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders.DCs pulsed with novel HLA-A2-restricted CTL epitopes against hepatitis C virus induced a broadly reactive anti-HCV-specific T lymphocyte response.Loss and dysfunction of Vδ2⁺ γδ T cells are associated with clinical tolerance to malaria.IL-10 mediated regulation of liver inflammation during acute murine cytomegalovirus infection Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques TIM-3 does not act as a receptor for galectin-9.

P2860

Q26753195-DB871941-83A4-48EB-8DE1-6D98BDE95ECE Q26765459-88EEFB5B-045E-4F8F-A670-CAF85A51548A Q26768530-0EC8916A-B2B0-4BDF-8344-A4BE4EF1D622 Q26823033-0A55CC76-C1CD-451B-910F-A23581CC6438 Q26829885-C179AAD2-A50B-4C96-A5B2-9EF00358E3E6 Q26866955-8099201C-BA34-4FE7-9EE1-63A9FCCCBD1D Q27002588-8FE2DE8A-2E33-4CC2-9D2D-7E1DA5777EAA Q27024580-EE6A9BC3-9A5D-46A7-B509-5308EE2BD125 Q28074434-9640155E-81CF-439E-99F8-2332ED85E07A Q28086907-9DDF6B83-7236-4359-AAEA-F794D100AE50 Q28506567-EBEB73C3-F557-4B31-8232-0DCF66B909E2 Q28510998-8B130EF3-4839-4386-BE1C-4FAAA7EE38B4 Q28540848-F9F67A02-2C4C-474E-AE7E-9103AA9655E2 Q30274847-53713E1C-F774-4530-9C0F-7F5FE427A502 Q30402699-16557785-DE90-4856-B126-DA0774C69C9A Q30409687-C6341AAC-3C59-4F42-819E-61B6C3C0014F Q30414014-772C92D6-78A3-4166-8432-4FD0358A1FBA Q30420186-B0757CC5-17D4-4E29-A76C-7CC8AC36A8C9 Q33404324-2B04DBA9-3DD2-447C-8BF6-9097F79404FF Q33408423-B518C411-912F-4258-A40D-ECF73F14F0BF Q33714165-1BD9B94F-CE49-4386-9E27-CF6684A76A1D Q33718778-E100B705-97C2-44FE-B6E6-2B84F8674031 Q33731047-6C5B8645-BBD7-4C3A-85C0-837EEDD71F86 Q33759224-CBC348A4-B9CA-4F0C-BA66-C183325B9CFF Q33816240-58DC45F1-3663-4980-8B10-CC990D4A8FD8 Q33826692-C5683A95-6B1C-45CA-A815-D80A5E1D250B Q33840260-C2D702D0-7FAB-4908-A0FD-528691107283 Q33923368-002A4011-11CB-4CA2-B10B-947786ECB30E Q34017074-207AE356-851A-41B5-877A-56B88812051C Q34075730-5835BFF0-D46F-4EBE-BCEF-D15C62059FEE Q34100837-75D53490-B843-4E07-93A5-A837334130B2 Q34178628-FC96C5C2-AE73-40A7-B379-61DBEC5B19D5 Q34195216-4E59B23E-311F-4906-BD23-0499B52D2909 Q34230483-18A8A906-F790-41E4-AD5B-A61413E3960D Q34305417-74EB0831-CA0F-4D97-9968-B41747E6FFDC Q34343795-880348A3-5CE4-49F4-9C3F-867123F2A25A Q34374800-BA404488-43F7-4BA0-A044-85C9B3A95F3D Q34462234-79743734-F546-4063-BC36-B8216023D300 Q34550643-E9379C35-3349-4965-A40A-CC855E7FEF31 Q34649690-BE790A96-BE85-4DDE-9E28-F1A002607FB8

P2860

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

http://www.wikidata.org/entity/Q34364103

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Tim-3 expression on PD-1+ HCV- ...... directed in vitro cytotoxicity

@ast

Tim-3 expression on PD-1+ HCV- ...... directed in vitro cytotoxicity

@en

Tim-3 expression on PD-1+ HCV- ...... directed in vitro cytotoxicity

@nl

type

label

Tim-3 expression on PD-1+ HCV- ...... directed in vitro cytotoxicity

@ast

Tim-3 expression on PD-1+ HCV- ...... directed in vitro cytotoxicity

@en

Tim-3 expression on PD-1+ HCV- ...... directed in vitro cytotoxicity

@nl

prefLabel

Tim-3 expression on PD-1+ HCV- ...... directed in vitro cytotoxicity

@ast

Tim-3 expression on PD-1+ HCV- ...... directed in vitro cytotoxicity

@en

Tim-3 expression on PD-1+ HCV- ...... directed in vitro cytotoxicity

@nl

P1433

Q34364103-687CCD25-E1C6-4C36-8A5B-5F41802E2F56

P1476

Q34364103-7C248968-9B67-47CC-887C-3492E020A671

P2093

Q34364103-374E02DA-8CE9-4FF0-B35A-92FC063F35F1

Q34364103-5C78CC23-46FC-4747-9120-1737DA6EF892

Q34364103-8498D29B-5116-41A4-A951-232FFF49C4BB

Q34364103-C43B0316-2AF4-4D29-A4A3-F035F121CE3B

Q34364103-D14C8852-C9FB-41DB-A1A0-672158CA5ED6

Q34364103-E7B597E8-D467-42AB-A93E-5676FE852EB1

Q34364103-EAF5D4EB-09F3-4737-958B-066015A4B6A9

Q34364103-F8B382D4-29DE-472F-82A3-B1ED1B414189

P2860

Q34364103-016A924A-2400-4435-825D-B3BEE444E210

Q34364103-046C5125-EFED-46EC-AE46-834FB25C5C6B

Q34364103-06259AC8-E1EE-41E1-AADF-980D765929E9

Q34364103-0B199F2B-4A2D-4039-B981-DE2755618933

Q34364103-0C1254D9-A74D-492A-9DDD-E97ED20098AB

Q34364103-0C9A1540-64F4-4ECA-A32B-61D9BB739C87

Q34364103-0E12C18F-470E-41AE-8F2C-6882B197C05C

Q34364103-113013EB-DC7C-4DC7-BB55-357B59DBE1AC

Q34364103-123020DA-E78D-446D-9899-28AC341E4715

Q34364103-19FE634E-DAF2-4F88-AED4-579D18A6DFA8

P304

Q34364103-21402351-7B7A-4E23-8C0F-ECA503403BAC

P31

Q34364103-B7F2DC28-A578-4AE9-9530-9EA94FC52989

P356

Q34364103-B71E7A65-7769-450B-A9C6-ADBF40C4B709

P407

Q34364103-D07F23CE-497E-46F1-BA9F-3B147750ACEA

P433

Q34364103-D97FC5DC-23E6-4144-A2EA-19EA1988ADE4

P478

Q34364103-D16C2158-8C9C-47FF-B270-1E0459AC46A9

P50

Q34364103-0B257F5B-E822-4EB9-B8CC-2D6C7C578255

P577

Q34364103-7640D3E2-4B0E-424B-82A4-C9F8AC676AD8

P698

Q34364103-9134D306-1741-41FB-A216-1FDF7919A2BC

P921

Q34364103-63A440A5-08E2-4D5B-9396-B5D043BD1CF4

Q34364103-9D279704-7ABE-499C-82B4-77AA6A9CE6B8

P932

Q34364103-4EF80EED-B347-478A-8914-C1516FF147EC

P356

P1433

Journal of Clinical Investigation

P1476

Tim-3 expression on PD-1+ HCV- ...... directed in vitro cytotoxicity

@en

P2093

Brian J McMahon

http://www.w3.org/2001/XMLSchema#string

David R Gretch

http://www.w3.org/2001/XMLSchema#string

Hugo R Rosen

http://www.w3.org/2001/XMLSchema#string

Lucy Golden-Mason

http://www.w3.org/2001/XMLSchema#string

Michael I Nishimura

http://www.w3.org/2001/XMLSchema#string

Michael Kemper

http://www.w3.org/2001/XMLSchema#string

Rachel H McMahan

http://www.w3.org/2001/XMLSchema#string

Todd M Allen

http://www.w3.org/2001/XMLSchema#string

P2860

A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection

BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination

Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction

Viral Sequence Evolution in Acute Hepatitis C Virus Infection

Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man

Cellular immune selection with hepatitis C virus persistence in humans

Immune evasion versus recovery after acute hepatitis C virus infection from a shared source

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

P304

4546-4557

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI43127

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

120

http://www.w3.org/2001/XMLSchema#string

P50

Lucy Golden-Mason

P577

2010-11-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

21084749

http://www.w3.org/2001/XMLSchema#string

P921

viral persistence

P932

2994339

http://www.w3.org/2001/XMLSchema#string