The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform.
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In silico toxicology: computational methods for the prediction of chemical toxicityEnvironmental Chemical Assessment in Clinical Practice: Unveiling the Elephant in the RoomAggregating data for computational toxicology applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) SystemThe Tox21 robotic platform for the assessment of environmental chemicals--from vision to realityBig data in chemical toxicity research: the use of high-throughput screening assays to identify potential toxicantsInsulin resistance and environmental pollutants: experimental evidence and future perspectivesAssessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesisTranscriptomic characterization of C57BL/6 mouse embryonic stem cell differentiation and its modulation by developmental toxicantsPerspectives on validation of high-throughput assays supporting 21st century toxicity testingPredictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay dataCERAPP: Collaborative Estrogen Receptor Activity Prediction ProjectIntersection of toxicogenomics and high throughput screening in the Tox21 program: an NIEHS perspectiveParadigm shift in toxicity testing and modeling.A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling.Low-Dose Dose-Response for In Vitro Nrf2-ARE Activation in Human HepG2 CellsNon-monotonic dose responses in studies of endocrine disrupting chemicals: bisphenol a as a case studyAssessment of compound hepatotoxicity using human plateable cryopreserved hepatocytes in a 1536-well-plate format.Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach.A three-stage algorithm to make toxicologically relevant activity calls from quantitative high throughput screening dataA new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential.Cross-species toxicogenomic analyses and phenotypic anchoring in response to groundwater low-level pollutionFunctional toxicogenomics: mechanism-centered toxicology.Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform.Adaptation of high-throughput screening in drug discovery-toxicological screening tests.Obesogens, stem cells and the developmental programming of obesity.Bisphenol A diglycidyl ether induces adipogenic differentiation of multipotent stromal stem cells through a peroxisome proliferator-activated receptor gamma-independent mechanism.Mapping Proteome-Wide Targets of Environmental Chemicals Using Reactivity-Based Chemoproteomic PlatformsIsotonic Regression Based-Method in Quantitative High-Throughput Screenings for Genotoxicity.Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library.In vitro bioassays to evaluate complex chemical mixtures in recycled water.Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.A Quantitative Approach to Screen for Nephrotoxic Compounds In VitroProfiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assaysReengineering translational science: the time is right.Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells.Comment on "On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens".From QSAR to QSIIR: searching for enhanced computational toxicology models.Three-dimensionally engineered biomimetic tissue models for in vitro drug evaluation: delivery, efficacy and toxicity.Editor's Highlight: Genetic Targets of Acute Toluene Inhalation in Drosophila melanogaster.
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The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The future of toxicity testing ...... throughput screening platform.
@ast
The future of toxicity testing ...... throughput screening platform.
@en
The future of toxicity testing ...... throughput screening platform.
@nl
type
label
The future of toxicity testing ...... throughput screening platform.
@ast
The future of toxicity testing ...... throughput screening platform.
@en
The future of toxicity testing ...... throughput screening platform.
@nl
prefLabel
The future of toxicity testing ...... throughput screening platform.
@ast
The future of toxicity testing ...... throughput screening platform.
@en
The future of toxicity testing ...... throughput screening platform.
@nl
P2093
P2860
P1433
P1476
The future of toxicity testing ...... throughput screening platform.
@en
P2093
Menghang Xia
Ruili Huang
Sunita J Shukla
P2860
P304
P356
10.1016/J.DRUDIS.2010.07.007
P577
2010-08-11T00:00:00Z