Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).
about
Intraperitoneal Infection of Wild-Type Mice with Synthetically Generated Mammalian PrionEx vivo mammalian prions are formed of paired double helical prion protein fibrils.Role of polysaccharide and lipid in lipopolysaccharide induced prion protein conversionUptake and degradation of protease-sensitive and -resistant forms of abnormal human prion protein aggregates by human astrocytes.Quaternary structure of pathological prion protein as a determining factor of strain-specific prion replication dynamics.Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestationStructural determinants of phenotypic diversity and replication rate of human prions.Pyroglutamyl-N-terminal prion protein fragments in sheep brain following the development of transmissible spongiform encephalopathies.Prion Infectivity Plateaus and Conversion to Symptomatic Disease Originate from Falling Precursor Levels and Increased Levels of Oligomeric PrPSc Species.Disease-associated mutations in the prion protein impair laminin-induced process outgrowth and survivalStrain-dependent profile of misfolded prion protein aggregates.PrPSc-Specific Antibody Reveals C-Terminal Conformational Differences between Prion Strains.Prions: Beyond a Single Protein.Distinct prion-like strains of amyloid beta implicated in phenotypic diversity of Alzheimer's disease.Analyses of protease resistance and aggregation state of abnormal prion protein across the spectrum of human prionsCo-existence of distinct prion types enables conformational evolution of human PrPSc by competitive selectionRapidly progressive Alzheimer's disease features distinct structures of amyloid-β.Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification.Prion protein misfolding, strains, and neurotoxicity: an update from studies on Mammalian prions.Prion disease tempo determined by host-dependent substrate reduction.Novel strain properties distinguishing sporadic prion diseases sharing prion protein genotype and prion type.Prion nucleation site unmasked by transient interaction with phospholipid cofactor.Pathogenic mutations within the hydrophobic domain of the prion protein lead to the formation of protease-sensitive prion species with increased lethality.Peripherally administrated prions reach the brain at sub-infectious quantities in experimental hamsters.Implications of prion adaptation and evolution paradigm for human neurodegenerative diseases.Prions and Protein Assemblies that Convey Biological Information in Health and Disease.Drosophila models of prionopathies: insight into prion protein function, transmission, and neurotoxicity.Diagnostic and prognostic value of human prion detection in cerebrospinal fluid.Distinct tau prion strains propagate in cells and mice and define different tauopathies.A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.Prion Diseases.Artificial strain of human prions created in vitro.
P2860
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P2860
Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Small protease sensitive oligo ...... termine conversion rate of PrP
@nl
Small protease sensitive oligo ...... ine conversion rate of PrP(C).
@ast
Small protease sensitive oligo ...... ine conversion rate of PrP(C).
@en
type
label
Small protease sensitive oligo ...... termine conversion rate of PrP
@nl
Small protease sensitive oligo ...... ine conversion rate of PrP(C).
@ast
Small protease sensitive oligo ...... ine conversion rate of PrP(C).
@en
prefLabel
Small protease sensitive oligo ...... termine conversion rate of PrP
@nl
Small protease sensitive oligo ...... ine conversion rate of PrP(C).
@ast
Small protease sensitive oligo ...... ine conversion rate of PrP(C).
@en
P2093
P2860
P1433
P1476
Small protease sensitive oligo ...... ine conversion rate of PrP(C).
@en
P2093
Glenn C Telling
Janis Blevins
Jiri G Safar
Krystyna Surewicz
Man-Sun Sy
Mark Cohen
Qingzhong Kong
Tracy Haldiman
P2860
P304
P356
10.1371/JOURNAL.PPAT.1002835
P577
2012-08-02T00:00:00Z