Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors

Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors

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http://www.wikidata.org/entity/Q34372994

Q34372994

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Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response Leaving the lysosome behind: novel developments in autophagy inhibition Targeting autophagy in cancer management - strategies and developments You eat what you are: autophagy inhibition as a therapeutic strategy in leukemia Autophagy in cancer Autophagy in malignant transformation and cancer progression Emerging strategies to effectively target autophagy in cancer Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers Therapeutic Targeting of Autophagy Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme.Addition of rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic solid tumors: a pilot safety and effectiveness analysis in a small patient cohort Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma.Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma.Molecular pathways: autophagy in cancer--a matter of timing and context.Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents.Histone deacetylase 3 inhibits new tumor suppressor gene DTWD1 in gastric cancer.Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion.The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities.Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy.Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission.Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia.Safety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma.Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1.Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin Therapeutic Approaches to RAS Mutation.Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy.Vorinostat and hydroxychloroquine improve immunity and inhibit autophagy in metastatic colorectal cancer.Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors.Cellular and metabolic functions for autophagy in cancer cells.Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy.

P2860

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P2860

Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors

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2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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