Abnormal centrosome amplification in the absence of p53.
about
Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerThe p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancersGADD45 induction of a G2/M cell cycle checkpointA novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrityRoles of BRCA1 in centrosome duplicationKIAA0101 interacts with BRCA1 and regulates centrosome numberWip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent mannerEmbryonic stem cells and somatic cells differ in mutation frequency and typeSuppression of the STK15 oncogenic activity requires a transactivation-independent p53 functionCentrosome amplification drives chromosomal instability in breast tumor development.Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cellsThe centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1pTranslocation of XRCC1 and DNA ligase IIIalpha from centrosomes to chromosomes in response to DNA damage in mitotic human cellsMicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survivalp53 regulates a G2 checkpoint through cyclin B1A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidizationCharacterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cellsCyclin-dependent kinase control of centrosome duplicationMolecular genetic analysis of giant cell glioblastomasExpression of cyclins A, E and topoisomerase II alpha correlates with centrosome amplification and genomic instability and influences the reliability of cytometric S-phase determinationAbsence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest.Preclinical Murine Models for Lung Cancer: Clinical Trial ApplicationsCentrosomes, chromosome instability (CIN) and aneuploidyCentrosomal nucleolin is required for microtubule network organization.Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2Functional Significance of Aurora Kinases-p53 Protein Family Interactions in CancerDrugging the addict: non-oncogene addiction as a target for cancer therapyDNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformationAssociation with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45Initiation of genome instability and preneoplastic processes through loss of Fhit expressionTumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-DuplicationComponents of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycleEukaryotic cells and their cell bodies: Cell Theory revisedThe antioxidant function of the p53 tumor suppressorMutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.Hbo1 Links p53-dependent stress signaling to DNA replication licensing.Differential regulation of centrosome integrity by DNA damage response proteins.Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.
P2860
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P2860
Abnormal centrosome amplification in the absence of p53.
description
1996 nî lūn-bûn
@nan
1996 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մարտին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Abnormal centrosome amplification in the absence of p53.
@ast
Abnormal centrosome amplification in the absence of p53.
@en
Abnormal centrosome amplification in the absence of p53.
@nl
type
label
Abnormal centrosome amplification in the absence of p53.
@ast
Abnormal centrosome amplification in the absence of p53.
@en
Abnormal centrosome amplification in the absence of p53.
@nl
prefLabel
Abnormal centrosome amplification in the absence of p53.
@ast
Abnormal centrosome amplification in the absence of p53.
@en
Abnormal centrosome amplification in the absence of p53.
@nl
P2093
P1433
P1476
Abnormal centrosome amplification in the absence of p53.
@en
P2093
P304
P356
10.1126/SCIENCE.271.5256.1744
P407
P577
1996-03-01T00:00:00Z