Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. - Wikidata - wikimedia - TriplyDB

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.

http://www.wikidata.org/entity/Q34376497

about

Programmable DNA-binding proteins from Burkholderia provide a fresh perspective on the TALE-like repeat domain Genome Engineering with TALE and CRISPR Systems in Neuroscience Understanding Spatial Genome Organization: Methods and Insights Applications of Engineered DNA-Binding Molecules Such as TAL Proteins and the CRISPR/Cas System in Biology Research From Gene Targeting to Genome Editing: Transgenic animals applications and beyond Enabling functional genomics with genome engineering Strategies for precision modulation of gene expression by epigenome editing: an overview Histone modifications and a choice of variant: a language that helps the genome express itself Chromatin features and the epigenetic regulation of pluripotency states in ESCs Epigenome engineering in cancer: fairytale or a realistic path to the clinic?Synthetic biology in mammalian cells: next generation research tools and therapeutics Making designer mutants in model organisms The epigenome: the next substrate for engineering CRISPR-Mediated Epigenome Editing Editing the Neuronal Genome: a CRISPR View of Chromatin Regulation in Neuronal Development, Function, and Plasticity CRISPR-Cas9: Tool for Qualitative and Quantitative Plant Genome Editing Epigenetic Editing: On the Verge of Reprogramming Gene Expression at Will Programming and inheritance of parental DNA methylomes in vertebrates Chromatin regulation at the frontier of synthetic biology Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory Development and applications of CRISPR-Cas9 for genome engineering.Dioxin induces Ahr-dependent robust DNA demethylation of the Cyp1a1 promoter via Tdg in the mouse liver CRISPR-Cas systems for editing, regulating and targeting genomes Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells.Dynamics of epigenetic regulation at the single-cell level.Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase.Principles and applications of TAL effectors for plant physiology and metabolism Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein.Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.A CRISPR-based approach for targeted DNA demethylation.Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies.DNA modifications in the mammalian brain Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.New approaches to manipulating the epigenome.Optimized tuning of TALEN specificity using non-conventional RVDs.Direct observation of TALE protein dynamics reveals a two-state search mechanism

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Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.

http://www.wikidata.org/entity/Q34376497

description

2013 nî lūn-bûn

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2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

@zh-sg

2013年學術文章

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name

Targeted DNA demethylation and ...... ble TALE-TET1 fusion proteins.

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Targeted DNA demethylation and ...... ble TALE-TET1 fusion proteins.

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Targeted DNA demethylation and ...... ble TALE-TET1 fusion proteins.

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type

label

Targeted DNA demethylation and ...... ble TALE-TET1 fusion proteins.

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Targeted DNA demethylation and ...... ble TALE-TET1 fusion proteins.

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Targeted DNA demethylation and ...... ble TALE-TET1 fusion proteins.

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prefLabel

Targeted DNA demethylation and ...... ble TALE-TET1 fusion proteins.

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Targeted DNA demethylation and ...... ble TALE-TET1 fusion proteins.

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Targeted DNA demethylation and ...... ble TALE-TET1 fusion proteins.

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Nature Biotechnology

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Targeted DNA demethylation and ...... ble TALE-TET1 fusion proteins.

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Bradley E Bernstein

http://www.w3.org/2001/XMLSchema#string

Deepak Reyon

http://www.w3.org/2001/XMLSchema#string

J Keith Joung

http://www.w3.org/2001/XMLSchema#string

James F Angstman

http://www.w3.org/2001/XMLSchema#string

Jeffry D Sander

http://www.w3.org/2001/XMLSchema#string

Joseph F Costello

http://www.w3.org/2001/XMLSchema#string

Marcy E Richardson

http://www.w3.org/2001/XMLSchema#string

Miles F Wilkinson

http://www.w3.org/2001/XMLSchema#string

Morgan L Maeder

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Quan H Ho

http://www.w3.org/2001/XMLSchema#string

P2860

DNA methylation patterns and epigenetic memory

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

Site-selective in vivo targeting of cytosine-5 DNA methylation by zinc-finger proteins

Epigenetic reprogramming in mammalian development

A TALE nuclease architecture for efficient genome editing

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1137-1142

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scholarly article

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10.1038/NBT.2726

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12

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31

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2013-10-09T00:00:00Z

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24108092

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3858462

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