3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
about
An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenonesD2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHDAntagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626.Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulationsAnalogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SARThe azaindole framework in the design of kinase inhibitorsDopamine D4 receptors in psychostimulant addictionVisualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level.CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full AgonistThe Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling TaskDopamine D4 receptor-mediated presynaptic inhibition of GABAergic transmission in the rat supraoptic nucleusThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsBDNF-TrkB signaling in striatopallidal neurons controls inhibition of locomotor behavior.Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown.Subtype selectivity of dopamine receptor ligands: insights from structure and ligand-based methodsIdentification of a new selective dopamine D4 receptor ligand.Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior.Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.Fyn is required for haloperidol-induced catalepsy in mice.Developments in the pharmacological treatment of schizophrenia.Drug induced increases in CNS dopamine alter monocyte, macrophage and T cell functions: implications for HAND.Striatal and extrastriatal microPET imaging of D2/D3 dopamine receptors in rat brain with [¹⁸F]fallypride and [¹⁸F]desmethoxyfallypridePalladium-catalyzed amination of unprotected halo-7-azaindolesStructure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.Dopamine receptor repertoire of human granulosa cells.Dopamine receptors in human embryonic stem cell neurodifferentiation.Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.Nicotine modulation of adolescent dopamine receptor signaling and hypothalamic peptide response.Implication of dorsostriatal D3 receptors in motivational processes: a potential target for neuropsychiatric symptoms in Parkinson's disease.PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion.Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex.A general, enantioselective synthesis of protected morpholines and piperazines.Enantioselective synthesis of C2-functionalized, N-protected morpholines and orthogonally N,N'-protected piperazines via organocatalysisDopaminergic profile of new heterocyclic N-phenylpiperazine derivatives.Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats.Role of Dopamine Receptors in the Anticancer Activity of ONC201.Control of the subthalamic innervation of the rat globus pallidus by D2/3 and D4 dopamine receptors.In vitro and in vivo evaluation of N-{2-[4-(3-Cyanopyridin-2-yl)piperazin-1-yl]ethyl}-3-[(11) C]methoxybenz-amide, a positron emission tomography (PET) radioligand for dopamine D4 receptors, in rodents.Dopamine presynaptically depresses fast inhibitory synaptic transmission via D4 receptor-protein kinase A pathway in the rat dorsolateral septal nucleus.Synthesis of novel sugar-lactam conjugates using the Aubé reaction.
P2860
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P2860
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
description
1996 nî lūn-bûn
@nan
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
3-((4-(4-Chlorophenyl)piperazi ...... he human dopamine D4 receptor.
@ast
3-((4-(4-Chlorophenyl)piperazi ...... he human dopamine D4 receptor.
@en
3-((4-(4-Chlorophenyl)piperazi ...... he human dopamine D4 receptor.
@nl
type
label
3-((4-(4-Chlorophenyl)piperazi ...... he human dopamine D4 receptor.
@ast
3-((4-(4-Chlorophenyl)piperazi ...... he human dopamine D4 receptor.
@en
3-((4-(4-Chlorophenyl)piperazi ...... he human dopamine D4 receptor.
@nl
prefLabel
3-((4-(4-Chlorophenyl)piperazi ...... he human dopamine D4 receptor.
@ast
3-((4-(4-Chlorophenyl)piperazi ...... he human dopamine D4 receptor.
@en
3-((4-(4-Chlorophenyl)piperazi ...... he human dopamine D4 receptor.
@nl
P2093
P356
P1476
3-((4-(4-Chlorophenyl)piperazi ...... he human dopamine D4 receptor.
@en
P2093
Broughton HB
Freedman SB
Kulagowski JJ
P304
P356
10.1021/JM9600712
P407
P577
1996-05-01T00:00:00Z