Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction - Wikidata - wikimedia - TriplyDB

Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction

Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction

http://www.wikidata.org/entity/Q34383442

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Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design New dimension in therapeutic targeting of BCL-2 family proteins.Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.

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Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction

http://www.wikidata.org/entity/Q34383442

description

2012 nî lūn-bûn

@nan

2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հուլիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Synthesis and evaluation of su ...... f the Mcl-1/BimBH3 interaction

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Synthesis and evaluation of su ...... f the Mcl-1/BimBH3 interaction

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Synthesis and evaluation of su ...... f the Mcl-1/BimBH3 interaction

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type

label

Synthesis and evaluation of su ...... f the Mcl-1/BimBH3 interaction

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Synthesis and evaluation of su ...... f the Mcl-1/BimBH3 interaction

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Synthesis and evaluation of su ...... f the Mcl-1/BimBH3 interaction

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prefLabel

Synthesis and evaluation of su ...... f the Mcl-1/BimBH3 interaction

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Synthesis and evaluation of su ...... f the Mcl-1/BimBH3 interaction

@en

Synthesis and evaluation of su ...... f the Mcl-1/BimBH3 interaction

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P356

J.BMCL.2012.07.050

P1433

Bioorganic & Medicinal Chemistry Letters

P1476

Synthesis and evaluation of su ...... f the Mcl-1/BimBH3 interaction

@en

P2093

Chih-Chi Andrew Hu

http://www.w3.org/2001/XMLSchema#string

Courtney DuBoulay

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Juan R Del Valle

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Kenichiro Doi

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Maria E Balasis

http://www.w3.org/2001/XMLSchema#string

Norbert Berndt

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Saïd M Sebti

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Wayne Guida

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Young B Kim

http://www.w3.org/2001/XMLSchema#string

P2860

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

The Bcl-2 apoptotic switch in cancer development and therapy

Structural insights into the degradation of Mcl-1 induced by BH3 domains

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

The BCL-2 protein family: opposing activities that mediate cell death

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy.

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner

Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

Life in the balance: how BH3-only proteins induce apoptosis.

P304

5961-5965

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scholarly article

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10.1016/J.BMCL.2012.07.050

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18

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22

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2012-07-24T00:00:00Z

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22901384

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3432503

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