Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. - Wikidata - wikimedia - TriplyDB

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

http://www.wikidata.org/entity/Q34385127

about

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia Self-association of human PCSK9 correlates with its LDLR-degrading activity Mutations in NOTCH1 cause aortic valve disease Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice Common variants at 30 loci contribute to polygenic dyslipidemia Targeted capture and massively parallel sequencing of 12 human exomes The PCSK9 decade Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor Associations among race/ethnicity, ApoC-III genotypes, and lipids in HIV-1-infected individuals on antiretroviral therapy.Unmet Needs in LDL-C Lowering: When Statins Won't Do!PCSK9 inhibition in the management of hyperlipidemia: focus on evolocumab New developments in atherosclerosis: clinical potential of PCSK9 inhibition Insights into blood lipids from rare variant discovery Cardiovascular pharmacogenomics: current status and future directions Exploring predisposition and treatment response--the promise of genomics Genome-scale neurogenetics: methodology and meaning New therapeutic principles in dyslipidaemia: focus on LDL and Lp(a) lowering drugs Genetics of lipid traits and relationship to coronary artery disease Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseases Cholesterol: the good, the bad, and the ugly - therapeutic targets for the treatment of dyslipidemia Molecular biology of PCSK9: its role in LDL metabolism Molecular basis for LDL receptor recognition by PCSK9 Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo Genome editing: the road of CRISPR/Cas9 from bench to clinic New Era of Lipid-Lowering Drugs Zebrafish small molecule screens: Taking the phenotypic plunge PCSK9 (Proprotein convertase subtilisin/kexin type 9) inhibitors: past, present, and the future Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform Therapeutic genome editing: prospects and challenges

P2860

Q21136366-B57C202D-BAA4-455F-AB98-3C7E6D473E68 Q24187425-0F8C7441-688A-46FD-8AED-98243E36D3A4 Q24294486-7B3ECC7A-230D-4889-8607-9CC2C5904C23 Q24298534-CFF62CB9-31C2-4874-9C1A-F03E7CB2E722 Q24299848-58558A08-6036-410B-BB05-2CB3BFB10DF0 Q24300790-40DF5944-7A82-427E-B70B-7B0496024FD5 Q24301635-6AC70AF7-752C-48C9-92AB-50523795777E Q24306591-10DB6C8F-A9D4-47D3-8402-F8AF93C7C503 Q24307999-3459F139-9A3E-48D9-95B4-79043AC2B3BE Q24311328-9909E989-580A-46E6-A749-28A774FA8F6E Q24598765-C80C1DE6-AF6E-413F-84CD-B7B608669DB0 Q24615381-4A15E151-DB59-419D-89FA-4695000C7026 Q24615397-32F309E0-1CB4-4F12-AA5A-C8F31D2D6935 Q24646644-CB4E3C10-1BF3-4DB9-BE8A-EF2ADC6416B7 Q24652495-46967068-0AF3-4A98-8A68-AD5EBD7A33FB Q24656186-897BDE4C-E508-44D5-A1FF-F597605D3CDC Q25255216-E0405BF1-BF54-475F-B114-57AC6BC68938 Q26741705-1A9DB87B-38AB-438F-B717-5E1D6FEF5506 Q26747776-8AACD10C-F7D7-49E7-ABAB-ADFBB51E1DA0 Q26783407-4D52E5ED-F7AA-442F-B7F9-A67D60AD4DC3 Q26799138-683D70DB-680A-4391-97C3-88D39BE25C5F Q26801183-CAF10339-F4B3-4499-99A5-23FAF0B63162 Q26851609-BBCBA56C-ABBA-40E6-A5B3-56D28648498B Q26859474-094F60A8-FDC5-4530-87B9-347F0CD8BE3C Q26863369-987D7C7C-B1B0-48EB-BBB1-8FE792489581 Q26995252-75A99206-B67C-4B74-9C12-B18F052BD902 Q27003094-A90FBA3B-8542-4685-8113-5862EF3764A6 Q27009477-45852528-D8BE-457F-A830-819EC36AF1C1 Q27013494-BECBEA42-7C10-4000-85AB-703D046FD784 Q27488922-B198BB23-C3E1-4403-8946-1509288AF230 Q27649779-A72FDF8C-DBE7-4E70-8A27-7E1916DCB9CC Q27653836-D6698C3B-B37C-4B5A-8D05-6F595F28941D Q27655476-132F68CD-0AED-4AAC-B494-128B4E0A8E43 Q27665195-24EB21E8-868B-47E1-B495-9BED805D4F82 Q28066970-C52E1850-7120-482F-82B2-50D6C3D7E47C Q28072298-07BDF969-F1BC-4886-BD66-2CACAA855668 Q28073655-FC788A6B-8AF4-41FA-8BED-785519F9312E Q28083595-F53A0EB7-29CE-47EF-A7A6-5325111F7E74 Q28085421-7C427CC8-9306-40F9-B1E4-42D006CA2BC7 Q28087380-2313A81E-A31E-4B42-B2FF-20805CA8CB1B

P2860

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

http://www.wikidata.org/entity/Q34385127

description

2005 nî lūn-bûn

@nan

2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Low LDL cholesterol in individ ...... t nonsense mutations in PCSK9.

@ast

Low LDL cholesterol in individ ...... t nonsense mutations in PCSK9.

@en

Low LDL cholesterol in individ ...... t nonsense mutations in PCSK9.

@nl

type

label

Low LDL cholesterol in individ ...... t nonsense mutations in PCSK9.

@ast

Low LDL cholesterol in individ ...... t nonsense mutations in PCSK9.

@en

Low LDL cholesterol in individ ...... t nonsense mutations in PCSK9.

@nl

prefLabel

Low LDL cholesterol in individ ...... t nonsense mutations in PCSK9.

@ast

Low LDL cholesterol in individ ...... t nonsense mutations in PCSK9.

@en

Low LDL cholesterol in individ ...... t nonsense mutations in PCSK9.

@nl

P1433

Q34385127-0A674D70-BE85-4729-B460-899BAEC918EE

P1476

Q34385127-464BF320-C97A-4C97-9E68-323AB2C7112D

P2093

Q34385127-0607F102-2082-4C1E-864F-CBDE9F6DA3D7

Q34385127-5D35AA64-F1D2-4585-A1E5-10D679D7933D

Q34385127-DC388C61-3C58-4621-9EB1-C17D58E64A5F

Q34385127-EB54F68F-1ACC-4BF9-B2AD-B852F67DA0F9

Q34385127-F616FD31-F8EC-4482-AE5D-1B68EB6B778D

P2860

Q34385127-003F4A11-9F0F-467F-BAE6-E3228D5FC33C

Q34385127-101915A3-55EB-446F-A4C4-F45FE0EE4CDB

Q34385127-197E21DE-0DC4-4305-99C6-DF48D79312F5

Q34385127-357B4E28-5DB3-4AA1-8B2F-DF65E778DD94

Q34385127-398668F6-E9B0-459E-9C2D-CB3012D4C642

Q34385127-591C85DC-85CC-4C12-8680-76082440F7D2

Q34385127-8FE4EF82-EF78-4EB5-ABFE-43962A8A6413

Q34385127-93D0D5F9-F103-4287-A73E-DAC9BD7921CD

Q34385127-973D4760-5B0B-4A6D-A641-279F50F96484

Q34385127-A43C6B8F-80F3-4273-9061-09E72FA853D4

P2888

Q34385127-E531B5B9-9E06-483D-A56C-AFD70FC9C99E

P304

Q34385127-B52D8C0B-4D6F-429C-822E-764EFFB683D5

P31

Q34385127-29FA9F42-72E3-43E7-A5F2-F3CA2B387710

P356

Q34385127-2308F3E5-EB70-4876-AA1E-FBE9AB72DF01

P407

Q34385127-B633162D-748D-4DE5-B8C7-CD469AE706A5

P433

Q34385127-564A15C8-6871-4FC7-9CA5-B7A27FB83CD4

P478

Q34385127-FF8EA60E-CD28-46E1-80AB-DEB8437F3221

P50

Q34385127-6B473728-9677-46A5-B522-E19F8E87E095

P577

Q34385127-62D708F1-251E-48F2-9FC7-5E241DC0C47E

P5875

Q34385127-68FD1656-9FD8-46EF-A063-B861A18DF166

P698

Q34385127-39C88AC7-758C-4F15-B052-2DA414801BA1

P356

P1433

Nature Genetics

P1476

Low LDL cholesterol in individ ...... t nonsense mutations in PCSK9.

@en

P2093

Christine Kim Garcia

http://www.w3.org/2001/XMLSchema#string

Helen H Hobbs

http://www.w3.org/2001/XMLSchema#string

Ingrid K Kotowski

http://www.w3.org/2001/XMLSchema#string

Jonathan Cohen

http://www.w3.org/2001/XMLSchema#string

Randall Graham

http://www.w3.org/2001/XMLSchema#string

P2860

Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree.

Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia.

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.

Members of the low density lipoprotein receptor family mediate cell entry of a minor-group common cold virus

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice.

P2888

P304

161-165

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NG1509

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

37

http://www.w3.org/2001/XMLSchema#string

P50

Alexander Pertsemlidis

P577

2005-01-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8077738

http://www.w3.org/2001/XMLSchema#string

P698

15654334

http://www.w3.org/2001/XMLSchema#string