Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. - Wikidata - wikimedia - TriplyDB

Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia.

Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia.

http://www.wikidata.org/entity/Q34398498

about

The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice Aberrant Wnt Signaling in Leukemia Altered Expression of Genes in Signaling Pathways Regulating Proliferation of Hematopoietic Stem and Progenitor Cells in Mice with Subchronic Benzene Exposure MicroRNAs distinguish cytogenetic subgroups in pediatric AML and contribute to complex regulatory networks in AML-relevant pathways Wnt/beta-catenin signaling pathway is active in pancreatic development of rat embryo VentX trans-activates p53 and p16ink4a to regulate cellular senescence Activation of Wnt/β-catenin protein signaling induces mitochondria-mediated apoptosis in hematopoietic progenitor cells Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis Inhibiting CCN1 blocks AML cell growth by disrupting the MEK/ERK pathway.The role of LEF1 in endometrial gland formation and carcinogenesis Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.Activation of β-catenin signalling leads to temporomandibular joint defects.Wnt/β-catenin Pathway Modulates the Sensitivity of the Mutant FLT3 Receptor Kinase Inhibitors in a GSK-3β Dependent Manner.Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia.Anti-Proliferation Activity of Fucoidan in MKN45 Gastric Cancer Cells and Downregulation of Phosphorylated ASK1, a Cell Cycle-Regulated Kinase Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways.Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation The aryl hydrocarbon receptor pathway: a key component of the microRNA-mediated AML signalisome.Using bioinformatic approaches to identify pathways targeted by human leukemogens MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development.The role of Wnt signaling in cancer and stem cells.Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome.γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin mRNA stability control: a clandestine force in normal and malignant hematopoiesis.Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue.Fas-associated phosphatase 1 (Fap1) influences βcatenin activity in myeloid progenitor cells expressing the Bcr-abl oncogene Molecular mechanisms of drug resistance in acute myeloid leukaemia.Beta-catenin/LEF-1 signalling in breast cancer--central players activated by a plethora of inputs.Targeting cancer stem cells.Adult T-cell leukemia cells overexpress Wnt5a and promote osteoclast differentiation.KIT regulates tyrosine phosphorylation and nuclear localization of beta-catenin in mast cell leukemia.The leukemia-associated Mll-Ell oncoprotein induces fibroblast growth factor 2 (Fgf2)-dependent cytokine hypersensitivity in myeloid progenitor cells.CXXC5 (retinoid-inducible nuclear factor, RINF) is a potential therapeutic target in high-risk human acute myeloid leukemia Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax.Integrin alphavbeta3 enhances β-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers.Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation.

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Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia.

http://www.wikidata.org/entity/Q34398498

description

2005 nî lūn-bûn

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2005 թուականի Մարտին հրատարակուած գիտական յօդուած

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Constitutive activation of the ...... ay in acute myeloid leukaemia.

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Constitutive activation of the ...... ay in acute myeloid leukaemia.

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Constitutive activation of the ...... ay in acute myeloid leukaemia.

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Constitutive activation of the ...... ay in acute myeloid leukaemia.

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Asim Khwaja

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David C Linch

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Maria Simon

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Victoria L Grandage

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Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

The cadherin-catenin adhesion system in signaling and cancer.

Genetics of myeloid leukemias.

Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.

Beta-catenin is dispensable for hematopoiesis and lymphopoiesis

Rapid and highly efficient gene transfer into natural killer cells by nucleofection.

Variable product purity and functional capacity after CD34 selection: a direct comparison of the CliniMACS (v2.1) and Isolex 300i (v2.5) clinical scale devices.

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10.1038/SJ.ONC.1208431

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