Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
about
Identification of potential conserved RNA secondary structure throughout influenza A coding regionsSmall molecules targeting viral RNATargeted inhibition of the hepatitis C internal ribosomal entry site genomic RNA with oligonucleotide conjugatesEncapsulating streptomycin within a small 40-mer RNASimultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat proteinEssential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat proteinDesign of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells3D RNA and Functional Interactions from Evolutionary CouplingsStructure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity.Ametantrone-based compounds as potential regulators of Tau pre-mRNA alternative splicing.Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication.Hoechst 33258 selectively inhibits group I intron self-splicing by affecting RNA folding.Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis.Fluorescent pyrimidine ribonucleotide: synthesis, enzymatic incorporation, and utilization.Screening helix-threading peptides for RNA binding using a thiazole orange displacement assaySmall molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intronMethods to enable the design of bioactive small molecules targeting RNA.A mutate-and-map strategy accurately infers the base pairs of a 35-nucleotide model RNAFootprinting, circular dichroism and UV melting studies on neomycin B binding to the packaging region of human immunodeficiency virus type-1 RNA.Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysisTargeting RNA by small molecules: comparative structural and thermodynamic aspects of aristololactam-β-D-glucoside and daunomycin binding to tRNA(phe)Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.Polymorphic nucleic Acid binding of bioactive isoquinoline alkaloids and their role in cancer.Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design.Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcriptsProbing a 2-aminobenzimidazole library for binding to RNA internal loops via two-dimensional combinatorial screening.Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations.Telomerase inhibitors for the treatment of cancer: the current perspective.FRET enabled real time detection of RNA-small molecule binding.Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites.Structural characterization of naturally occurring RNA single mismatches.Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy.Binding of the 9-O-N-aryl/arylalkyl amino carbonyl methyl substituted berberine analogs to tRNA(phe.).Defining RNA motif-aminoglycoside interactions via two-dimensional combinatorial screening and structure-activity relationships through sequencing.Heterogeneous Cu(II) -catalysed solvent-controlled selective N-arylation of cyclic amides and amines with bromo-iodoarenes.Molecular recognition of 6'-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches.Development and application of aromatic [(13)C, (1)H] SOFAST-HMQC NMR experiment for nucleic acids.RNA as a target for developing antivirals.RNA Structures as Mediators of Neurological Diseases and as Drug Targets.
P2860
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P2860
Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
@ast
Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
@en
Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
@nl
type
label
Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
@ast
Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
@en
Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
@nl
prefLabel
Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
@ast
Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
@en
Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
@nl
P356
P1476
Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges.
@en
P2093
P304
P356
10.1021/AR000118K
P407
P577
2001-10-01T00:00:00Z