GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity.
about
Integration of vestibular and emetic gastrointestinal signals that produce nausea and vomiting: potential contributions to motion sicknessIdentification of neural networks that contribute to motion sickness through principal components analysis of fos labeling induced by galvanic vestibular stimulationAnxiolytic-like effects of the neurokinin 1 receptor antagonist GR-205171 in the elevated plus maze and contextual fear-potentiated startle model of anxiety in gerbils.Synthesis of two potential NK1-receptor ligands using [1-11C]ethyl iodide and [1-11C]propyl iodide and initial PET-imaging.New insights into the antidepressant actions of substance P (NK1 receptor) antagonists.Evaluating the various phases of cisplatin-induced emesis in rats.Netupitant PET imaging and ADME studies in humans.Pharmacotherapy of postoperative nausea and vomiting.[3H]GR205171 displays similar NK1 receptor binding profile in gerbil and human brain.Integrative responses of neurons in nucleus tractus solitarius to visceral afferent stimulation and vestibular stimulation in vertical planes.Integrative responses of neurons in parabrachial nuclei to a nauseogenic gastrointestinal stimulus and vestibular stimulation in vertical planes.Comparison of the neurokinin-1 antagonist GR205171, alone and in combination with the 5-HT3 antagonist ondansetron, hyoscine and placebo in the prevention of motion-induced nausea in man.Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases.Effects of visceral inputs on the processing of labyrinthine signals by the inferior and caudal medial vestibular nuclei: ramifications for the production of motion sicknessIncreased neurokinin-1 receptor availability in the amygdala in social anxiety disorder: a positron emission tomography study with [11C]GR205171.Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT₃ receptor antagonistsMolecular imaging probes derived from natural peptides.Characterising the plasma-target occupancy relationship of the neurokinin antagonist GSK1144814 with PET.Purinergic P2X receptor activation induces emetic responses in ferrets and Suncus murinus (house musk shrews).Profile of Antiemetic Activity of Netupitant Alone or in Combination with Palonosetron and Dexamethasone in Ferrets and Suncus murinus (House Musk Shrew).Sustained pharmacological blockade of NK1 substance P receptors causes functional desensitization of dorsal raphe 5-HT 1A autoreceptors in mice.Selective blockade of neurokinin (NK)(1) receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats.Permissive role of neurokinin NK(3) receptors in NK(1) receptor-mediated activation of the locus coeruleus revealed by SR 142801.Identification of single-nucleotide polymorphisms of the human neurokinin 1 receptor gene and pharmacological characterization of a Y192H variant.The effects of ibuprofen and the neurokinin-1 receptor antagonist GR205171A on Fos expression in the ferret trigeminal nucleus following tooth pulp stimulation.The neurokinin-1 antagonist activity of maropitant, an antiemetic drug for dogs, in a gerbil model.Stereoselective and region-specific induction of immediate early gene expression in rat parietal cortex by blockade of neurokinin 1 receptors.Comparative efficacy of metoclopramide, ondansetron and maropitant in preventing parvoviral enteritis-induced emesis in dogs.Association between amygdala neurokinin-1 receptor availability and anxiety-related personality traitsAnti-emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT Antagonist, Palonosetron and With the NK Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in (House Musk Shrew)
P2860
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P2860
GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity.
description
1996 nî lūn-bûn
@nan
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
GR205171: a novel antagonist w ...... spectrum anti-emetic activity.
@ast
GR205171: a novel antagonist w ...... spectrum anti-emetic activity.
@en
GR205171: a novel antagonist w ...... spectrum anti-emetic activity.
@nl
type
label
GR205171: a novel antagonist w ...... spectrum anti-emetic activity.
@ast
GR205171: a novel antagonist w ...... spectrum anti-emetic activity.
@en
GR205171: a novel antagonist w ...... spectrum anti-emetic activity.
@nl
prefLabel
GR205171: a novel antagonist w ...... spectrum anti-emetic activity.
@ast
GR205171: a novel antagonist w ...... spectrum anti-emetic activity.
@en
GR205171: a novel antagonist w ...... spectrum anti-emetic activity.
@nl
P2093
P1433
P1476
GR205171: a novel antagonist w ...... spectrum anti-emetic activity.
@en
P2093
A B Hawcock
C J Gardner
D J Twissell
D R Armour
D T Beattie
G J Kilpatrick
P356
10.1016/0167-0115(96)00071-7
P577
1996-08-01T00:00:00Z