Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
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Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow MicroenvironmentImpact of genomic damage and ageing on stem cell functionChallenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Aging-Induced Stem Cell Mutations as Drivers for Disease and CancerToward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutationsStochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemiaAging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitorsEvolved tumor suppression: why are we so good at not getting cancer?Contribution of an aged microenvironment to aging-associated myeloproliferative disease.Leukemogenesis and ageing: 'fit for transformation'?What can ecology teach us about cancer?Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?Molecular damage in cancer: an argument for mTOR-driven agingNCI's provocative questions on cancer: some answers to ignite discussion.Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa BTumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?Aging promotes neoplastic disease through effects on the tissue microenvironment.Acute lymphoblastic leukemia and developmental biology: a crucial interrelationshipStat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis.STAT5 activation in B-cell acute lymphoblastic leukemia: damned if you do, damned if you don't.The evolution of lifespan and age-dependent cancer riskThe age of the target cell affects B-cell leukaemia malignancy.Population dynamics of normal and leukaemia stem cells in the haematopoietic stem cell niche show distinct regimes where leukaemia will be controlled.Stochastic modeling indicates that aging and somatic evolution in the hematopoetic system are driven by non-cell-autonomous processes.Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma.Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations.Regenerative Medicine: Shedding Light on the Link between Aging and Cancer.Molecular processes involved in B cell acute lymphoblastic leukaemia.Analysis of mutation, selection, and epistasis: an informed approach to cancer clinical trials.
P2860
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P2860
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
@ast
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
@en
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
@nl
type
label
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
@ast
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
@en
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
@nl
prefLabel
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
@ast
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
@en
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
@nl
P2093
P2860
P356
P1476
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis
@en
P2093
Andriy Marusyk
Biniam Adane
Curtis J Henry
Vadym Zaberezhnyy
P2860
P304
21713-21718
P356
10.1073/PNAS.1005486107
P407
P50
P577
2010-11-22T00:00:00Z