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Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

http://www.wikidata.org/entity/Q34412171

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Temperament type specific metabolite profiles of the prefrontal cortex and serum in cattle Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease No quiet surrender: molecular guardians in multiple sclerosis brain Modes of physiologic H2S signaling in the brain and peripheral tissues N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases New method for quantification of gasotransmitter hydrogen sulfide in biological matrices by LC-MS/MS.Photoacoustic probes for real-time tracking of endogenous H2S in living mice.Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea.Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation Protein kinase G-regulated production of H2S governs oxygen sensing.Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems.Cystathionine Levels in Patients With Huntington Disease Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase.Hydrogen sulfide and polysulfides as signaling molecules.Combination of lycopene, quercetin and poloxamer 188 alleviates anxiety and depression in 3-nitropropionic acid-induced Huntington's disease in rats Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington's disease.Transcriptional control of amino acid homeostasis is disrupted in Huntington's disease Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.Animal models of Huntington's disease for translation to the clinic: best practices.Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway.Overexpression of cystathionine γ-lyase suppresses detrimental effects of spinocerebellar ataxia type 3.Chemiluminescent Probes for Imaging H2S in Living Animals L-Cysteine metabolism and its nutritional implications.Main path and byways: non-vesicular glutamate release by system xc(-) as an important modifier of glutamatergic neurotransmission.H2S: A Novel Gasotransmitter that Signals by Sulfhydration.Huntington's Disease: Pathogenic Mechanisms and Therapeutic Targets.Dual-Emission Channels for Simultaneous Sensing of Cysteine and Homocysteine in Living Cells.The in vivo evidence for regulated necrosis.Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies.A New Hope for a Devastating Disease: Hydrogen Sulfide in Parkinson's Disease.Identification of Proteins Interacting with Cytoplasmic High-Mobility Group Box 1 during the Hepatocellular Response to Ischemia Reperfusion Injury.Role of hydrogen sulfide within the dorsal motor nucleus of the vagus in the control of gastric function in rats.

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Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

http://www.wikidata.org/entity/Q34412171

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

@zh-hk

2014年論文

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2014年論文

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2014年论文

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name

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

@ast

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

@en

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

@nl

type

label

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

@ast

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

@en

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

@nl

prefLabel

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

@ast

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

@en

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

@nl

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Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease

@en

P2093

Adele M Snowman

http://www.w3.org/2001/XMLSchema#string

Bindu D Paul

http://www.w3.org/2001/XMLSchema#string

Jiyoung Y Cha

http://www.w3.org/2001/XMLSchema#string

Juan I Sbodio

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M Scott Vandiver

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Risheng Xu

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P2860

Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase

Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression

H2S signals through protein S-sulfhydration.

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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96-100

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scholarly article

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10.1038/NATURE13136

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7498

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509

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Solomon Halbert Snyder

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2014-03-26T00:00:00Z

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1037896503

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24670645

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Huntington disease

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4349202

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