Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient mice
about
Gap junctional regulation of signal transduction in bone cellsConnexin 43 hemichannels and intracellular signaling in bone cellsThe Periosteal Bone Surface is Less Mechano-Responsive than the Endocortical.Resonance in the mouse tibia as a predictor of frequencies and locations of loading-induced bone formationIn situ intracellular calcium oscillations in osteocytes in intact mouse long bones under dynamic mechanical loading.Inhibition of GSK-3β rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice.Up-regulation of BMP2/4 signaling increases both osteoblast-specific marker expression and bone marrow adipogenesis in Gja1Jrt/+ stromal cell cultures.Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysisCx43 and mechanotransduction in bone.Deletion of connexin43 in osteoblasts/osteocytes leads to impaired muscle formation in mice.Connexins and pannexins in the skeleton: gap junctions, hemichannels and moreRole of connexins and pannexins during ontogeny, regeneration, and pathologies of boneDefective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain.Cortical and trabecular bone adaptation to incremental load magnitudes using the mouse tibial axial compression loading model.Connexins in the skeletonTranscriptional profiling of cortical versus cancellous bone from mechanically-loaded murine tibiae reveals differential gene expression.Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in miceConnexin43 modulates post-natal cortical bone modeling and mechano-responsiveness.Sclerostin's role in bone's adaptive response to mechanical loading.Molecular mechanisms of osteoblast/osteocyte regulation by connexin43.Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load.The "connexin" between bone cells and skeletal functions.Osteocytic signalling pathways as therapeutic targets for bone fragility.Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling.Joint diseases: from connexins to gap junctions.Bone mechanobiology in mice: toward single-cell in vivo mechanomics.The G60S connexin 43 mutation activates the osteoblast lineage and results in a resorption-stimulating bone matrix and abrogation of old-age-related bone loss.
P2860
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P2860
Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient mice
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2012 nî lūn-bûn
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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Enhanced periosteal and endoco ...... onal connexin43 deficient mice
@ast
Enhanced periosteal and endoco ...... onal connexin43 deficient mice
@en
Enhanced periosteal and endoco ...... onal connexin43 deficient mice
@nl
type
label
Enhanced periosteal and endoco ...... onal connexin43 deficient mice
@ast
Enhanced periosteal and endoco ...... onal connexin43 deficient mice
@en
Enhanced periosteal and endoco ...... onal connexin43 deficient mice
@nl
prefLabel
Enhanced periosteal and endoco ...... onal connexin43 deficient mice
@ast
Enhanced periosteal and endoco ...... onal connexin43 deficient mice
@en
Enhanced periosteal and endoco ...... onal connexin43 deficient mice
@nl
P2093
P2860
P1433
P1476
Enhanced periosteal and endoco ...... onal connexin43 deficient mice
@en
P2093
Marcus P Watkins
Matthew J Silva
Michael D Brodt
Roberto Civitelli
Susan K Grimston
P2860
P304
P356
10.1371/JOURNAL.PONE.0044222
P407
P577
2012-09-10T00:00:00Z