STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous system
about
Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous systemCoordinated Regulation and Widespread Cellular Expression of Interferon-Stimulated Genes (ISG) ISG-49, ISG-54, and ISG-56 in the Central Nervous System after Infection with Distinct VirusesDNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functionsInnate STAT1-dependent genomic response of neurons to the antiviral cytokine alpha interferon.Transgenic models for cytokine-induced neurological disease.Interferons, signal transduction pathways, and the central nervous system.Behavioral evaluation of transgenic mice with CNS expression of IFN-alpha by elevated plus-maze and Porsolt swim test.Stat1 negatively regulates immune-mediated injury with Anaplasma phagocytophilum infection.Cerebral expression of interleukin-12 induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice.Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain.Inflammatory impact of IFN-γ in CD8+ T cell-mediated lung injury is mediated by both Stat1-dependent and -independent pathways.Functional genomics reveals an essential and specific role for Stat1 in protection of the central nervous system following herpes simplex virus corneal infectionGene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- MicrogliaRole of signal transducer and activator of transcription 3 in neuronal survival and regenerationIFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice.Analysis of SOCS-3 promoter responses to interferon gamma.Protection from interferon-β-induced neuronal apoptosis through stimulation of muscarinic acetylcholine receptors coupled to ERK1/2 activation.Requirement of histone deacetylase activity for signaling by STAT1.Systemic interferon-alpha regulates interferon-stimulated genes in the central nervous system.Type I interferon-regulated gene expression and signaling in murine mixed glial cells lacking signal transducers and activators of transcription 1 or 2 or interferon regulatory factor 9.
P2860
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P2860
STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous system
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
STAT1 deficiency unexpectedly ...... in the central nervous system
@ast
STAT1 deficiency unexpectedly ...... in the central nervous system
@en
STAT1 deficiency unexpectedly ...... in the central nervous system
@nl
type
label
STAT1 deficiency unexpectedly ...... in the central nervous system
@ast
STAT1 deficiency unexpectedly ...... in the central nervous system
@en
STAT1 deficiency unexpectedly ...... in the central nervous system
@nl
prefLabel
STAT1 deficiency unexpectedly ...... in the central nervous system
@ast
STAT1 deficiency unexpectedly ...... in the central nervous system
@en
STAT1 deficiency unexpectedly ...... in the central nervous system
@nl
P2093
P2860
P356
P1476
STAT1 deficiency unexpectedly ...... in the central nervous system
@en
P2093
Iain L Campbell
Jianping Wang
Robert D Schreiber
P2860
P304
16209-16214
P356
10.1073/PNAS.252454799
P407
P577
2002-12-02T00:00:00Z