N-desmethylclobazam: a possible alternative to clobazam in the treatment of refractory epilepsy?

N-desmethylclobazam: a possible alternative to clobazam in the treatment of refractory epilepsy?

Item
http://www.wikidata.org/entity/Q34416248
Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for α₂- versus α₁-GABA(A)-receptor complexesDisappointing results of increasing benzodiazepine dose after the development of anticonvulsant tolerance.Peripheral benzodiazepine receptors in platelets of epileptic patientsEffects of clobazam and its active metabolite on GABA-activated currents in rat cerebral neurons in culture.The effect of cimetidine on the single dose pharmacokinetics of oral clobazam and N-desmethylclobazam.Pharmacokinetics of N-desmethylclobazam in healthy volunteers and patients with epilepsyThe clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia.Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studiesClobazam: a newly approved but well-established drug for the treatment of intractable epilepsy syndromes.Pharmacokinetic of antiepileptic drugs in patients with hepatic or renal impairment.Clobazam as an adjunctive therapy in treating seizures associated with Lennox-Gastaut syndrome.Interactions between modulators of the GABA(A) receptor: Stiripentol and benzodiazepinesPharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes.The effect of clobazam on steady state plasma concentrations of carbamazepine and its metabolites.Impact of CYP2C19 polymorphisms on the efficacy of clobazam therapy.PharmGKB summary: clobazam pathway, pharmacokinetics.
P2860

N-desmethylclobazam: a possible alternative to clobazam in the treatment of refractory epilepsy?

Item
http://www.wikidata.org/entity/Q34416248
description
1987 nî lūn-bûn
@nan
1987 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
N-desmethylclobazam: a possibl ...... atment of refractory epilepsy?
@ast
N-desmethylclobazam: a possibl ...... atment of refractory epilepsy?
@en
N-desmethylclobazam: a possibl ...... atment of refractory epilepsy?
@nl
type
label
N-desmethylclobazam: a possibl ...... atment of refractory epilepsy?
@ast
N-desmethylclobazam: a possibl ...... atment of refractory epilepsy?
@en
N-desmethylclobazam: a possibl ...... atment of refractory epilepsy?
@nl
prefLabel
N-desmethylclobazam: a possibl ...... atment of refractory epilepsy?
@ast
N-desmethylclobazam: a possibl ...... atment of refractory epilepsy?
@en
N-desmethylclobazam: a possibl ...... atment of refractory epilepsy?
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
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P433
P478
P577
P5875
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P932
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P1433
P1476
N-desmethylclobazam: a possibl ...... atment of refractory epilepsy?
@en
P2093
P2860
P304
P31
P356
10.1111/J.1365-2125.1987.TB03032.X
P407
P433
P478
P577
P5875
P698
P932