The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder.
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Functions of Ubiquitin and SUMO in DNA Replication and Replication StressCellular response to DNA interstrand crosslinks: the Fanconi anemia pathwayHow SUMOylation Fine-Tunes the Fanconi Anemia DNA Repair PathwayExploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer TherapyModulation of DNA damage and repair pathways by human tumour virusesEmerging critical roles of Fe-S clusters in DNA replication and repair.Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Stress and Non-Stress Roles of Inflammatory Signals during HSC Emergence and MaintenanceForkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage responseFancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in miceHow Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend InitiativeCellular Repair of DNA-DNA Cross-Links Induced by 1,2,3,4-Diepoxybutane.Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemiaThe Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCLUbiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance.DNA interstrand cross-link repair requires replication-fork convergence.DNA repair mechanisms in cancer development and therapyMutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.Protein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stabilityBiochemical mechanism of DSB end resection and its regulation.FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factorWhat is wrong with Fanconi anemia cells?FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex.Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent ChromiumThe Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiencyBrca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice.Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.Genes that Affect Brain Structure and Function Identified by Rare Variant Analyses of Mendelian Neurologic Disease.SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem CellsThe Simple Chordate Ciona intestinalis Has a Reduced Complement of Genes Associated with Fanconi Anemia.Nuclear alpha spectrin: Critical roles in DNA interstrand cross-link repair and genomic stability.BRCA2 minor transcript lacking exons 4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation.The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair.FANCD2 functions as a critical factor downstream of MiTF to maintain the proliferation and survival of melanoma cellsThe emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeuticsIncreasing sensitivity to DNA damage is a potential driver for human ovarian cancerThe FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2.Individuals with FANCM biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility.
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P2860
The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder.
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2014 nî lūn-bûn
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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2014 թվականի հունվարին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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The Fanconi anemia DNA repair ...... ights into a complex disorder.
@ast
The Fanconi anemia DNA repair ...... ights into a complex disorder.
@en
The Fanconi anemia DNA repair ...... ights into a complex disorder.
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type
label
The Fanconi anemia DNA repair ...... ights into a complex disorder.
@ast
The Fanconi anemia DNA repair ...... ights into a complex disorder.
@en
The Fanconi anemia DNA repair ...... ights into a complex disorder.
@nl
prefLabel
The Fanconi anemia DNA repair ...... ights into a complex disorder.
@ast
The Fanconi anemia DNA repair ...... ights into a complex disorder.
@en
The Fanconi anemia DNA repair ...... ights into a complex disorder.
@nl
P1476
The Fanconi anemia DNA repair ...... ights into a complex disorder.
@en
P2093
Helen Walden
P304
P356
10.1146/ANNUREV-BIOPHYS-051013-022737
P577
2014-01-01T00:00:00Z