Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target? - Wikidata - wikimedia - TriplyDB

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

http://www.wikidata.org/entity/Q34419108

about

Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease A novel monoclonal antibody against the N-terminus of Aβ1-42 reduces plaques and improves cognition in a mouse model of Alzheimer's disease.Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies.Alzheimer's Disease: Lessons Learned from Amyloidocentric Clinical Trials.Comparing the efficacy and neuroinflammatory potential of three anti-abeta antibodies Impact of interventions to reduce Alzheimer's disease pathology on the prevalence of dementia in the oldest-old.Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons.Ex vivo 18O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway Protein misfolding in neurodegenerative diseases: implications and strategies.Pharmacological approaches for Alzheimer's disease: neurotransmitter as drug targets.Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome?Familial Presenilin Mutations and Sporadic Alzheimer's Disease Pathology: Is the Assumption of Biochemical Equivalence Justified?A Toxic Conformer of Aβ42 with a Turn at 22-23 is a Novel Therapeutic Target for Alzheimer's Disease mCSM-AB: a web server for predicting antibody-antigen affinity changes upon mutation with graph-based signatures Erratum to: Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?Anti-Aβ antibody target engagement: a response to Siemers et al.Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.Anti-Aβ antibody target engagement: commentary regarding Watt et al. Acta Neuropathol 127:803-810 (2014).Clearing the way for tau immunotherapy in Alzheimer's disease.Molecular Docking and Dynamic Simulation of AZD3293 and Solanezumab Effects Against BACE1 to Treat Alzheimer's Disease.

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Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

http://www.wikidata.org/entity/Q34419108

description

2014 nî lūn-bûn

@nan

2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

@ast

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

@en

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

@nl

type

label

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

@ast

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

@en

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

@nl

prefLabel

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

@ast

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

@en

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

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S00401-014-1290-2

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Acta Neuropathologica

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Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

@en

P2093

Andrew D Watt

http://www.w3.org/2001/XMLSchema#string

Gabriela A N Crespi

http://www.w3.org/2001/XMLSchema#string

Kevin J Barnham

http://www.w3.org/2001/XMLSchema#string

Keyla A Perez

http://www.w3.org/2001/XMLSchema#string

Luke A Miles

http://www.w3.org/2001/XMLSchema#string

Russell A Down

http://www.w3.org/2001/XMLSchema#string

Victor L Villemagne

http://www.w3.org/2001/XMLSchema#string

P2860

Testing the right target and right drug at the right stage

Antibody multispecificity mediated by conformational diversity

Probability-based protein identification by searching sequence databases using mass spectrometry data

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Robust prediction of the MASCOT score for an improved quality assessment in mass spectrometric proteomics

Alzheimer's disease

Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics.

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis.

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study.

Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples.

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s00401-014-1290-2

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803-810

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scholarly article

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10.1007/S00401-014-1290-2

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6

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127

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Michael W Parker

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Alzheimer's disease