Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum
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Design of small molecule epigenetic modulatorsRecent advances in malaria drug discoveryPlasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasitesEnhanced Methylation Analysis by Recovery of Unsequenceable FragmentsHigh-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent MalariaDesigning synthetic drugs against Plasmodium falciparum: a computational study of histone-lysine N-methyltransferase (PfHKMT)MiR-30b Attenuates Neuropathic Pain by Regulating Voltage-Gated Sodium Channel Nav1.3 in Rats.Brain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor.Elucidating the molecular bases of epigenetic inheritance in non-model invertebrates: the case of the root-knot nematode Meloidogyne incognita.Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compoundsHistone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humansInhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06 Implication for Epigenetic Cancer Therapies.Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasitesInterrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites.An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptakeParasite epigenetics and immune evasion: lessons from budding yeast.G9a inhibits CREB-triggered expression of mu opioid receptor in primary sensory neurons following peripheral nerve injury.Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum.Post-translational protein modifications in malaria parasites.Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.Pharmacoepigenetics: an element of personalized therapy?The Role of Chromatin Structure in Gene Regulation of the Human Malaria Parasite.Malaria Epigenetics.Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a.Widespread occurrence of lysine methylation in Plasmodium falciparum proteins at asexual blood stages.Histone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available: SuppleHistone lysine methyltransferase structure activity relationships that allow for segregation of G9a inhibition and anti-Plasmodium activity.Chloroquine exposure triggers distinct cellular responses in sensitive versus resistant Plasmodium falciparum parasitesEpigenetics of Malaria ParasitesMechanisms Regulating Transcription inPlasmodium falciparumas Targets for Novel Antimalarial Drugs
P2860
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P2860
Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum
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2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Small-molecule histone methylt ...... forms in Plasmodium falciparum
@ast
Small-molecule histone methylt ...... forms in Plasmodium falciparum
@en
Small-molecule histone methylt ...... forms in Plasmodium falciparum
@nl
type
label
Small-molecule histone methylt ...... forms in Plasmodium falciparum
@ast
Small-molecule histone methylt ...... forms in Plasmodium falciparum
@en
Small-molecule histone methylt ...... forms in Plasmodium falciparum
@nl
prefLabel
Small-molecule histone methylt ...... forms in Plasmodium falciparum
@ast
Small-molecule histone methylt ...... forms in Plasmodium falciparum
@en
Small-molecule histone methylt ...... forms in Plasmodium falciparum
@nl
P2093
P2860
P356
P1476
Small-molecule histone methylt ...... forms in Plasmodium falciparum
@en
P2093
Artur Scherf
Salah Mecheri
Thomas A Moss
P2860
P304
16708-16713
P356
10.1073/PNAS.1205414109
P407
P577
2012-09-24T00:00:00Z