Structural insights into a yeast prion illuminate nucleation and strain diversity
about
Prion switching in response to environmental stressA scientific revolution? The prion anomaly may challenge the central dogma of molecular biologyThe role of the N-terminal oligopeptide repeats of the yeast Sup35 prion protein in propagation and transmission of prion variantsExpression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formationProbing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prionsAmyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structureYeast prions: structure, biology, and prion-handling systemsProbing the role of structural features of mouse PrP in yeast by expression as Sup35-PrP fusionsβ-Strand Flipping and Slipping Triggered by Turn Replacement Reveal the Opportunistic Nature of β-Strand PairingMolecular mechanisms for protein-encoded inheritanceStructural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin AHsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions.Rebels with a cause: molecular features and physiological consequences of yeast prionsStructure-based view on [PSI(+)] prion propertiesStability and structure of oligomers of the Alzheimer peptide Abeta16-22: from the dimer to the 32-merSpontaneous variants of the [RNQ+] prion in yeast demonstrate the extensive conformational diversity possible with prion proteinsSpatially resolved spectroscopic differentiation of hydrophilic and hydrophobic domains on individual insulin amyloid fibrilsProtein structure by mechanical triangulationEffect of charged residues in the N-domain of Sup35 protein on prion [PSI+] stability and propagation.Protein structure protection commits gene expression patterns.Heterologous cross-seeding mimics cross-species prion conversion in a yeast model.Sensitivity-enhanced NMR reveals alterations in protein structure by cellular milieusLattice model for amyloid peptides: OPEP force field parametrization and applications to the nucleus size of Alzheimer's peptides.Two amyloid States of the prion protein display significantly different folding patternsGetting a grip on prions: oligomers, amyloids, and pathological membrane interactions.A parallel microfluidic flow cytometer for high-content screening.Optical trapping with high forces reveals unexpected behaviors of prion fibrils.The Hsp104 N-terminal domain enables disaggregase plasticity and potentiationSynthesis and structural investigations of N-alkylated beta-peptidosulfonamide-peptide hybrids of the amyloidogenic amylin(20-29) sequence: Implications of supramolecular folding for the design of peptide-based bionanomaterials.A synergistic small-molecule combination directly eradicates diverse prion strain structuresInsight into the structure of amyloid fibrils from the analysis of globular proteins.Polyglutamine expansion mutation yields a pathological epitope linked to nucleation of protein aggregate: determinant of Huntington's disease onset.Metal ion-dependent, reversible, protein filament formation by designed beta-roll polypeptides.Prion protein insertional mutations increase aggregation propensity but not fiber stability.Heterologous prion interactions are altered by mutations in the prion protein Rnq1p.BETASCAN: probable beta-amyloids identified by pairwise probabilistic analysis.Distinct type of transmission barrier revealed by study of multiple prion determinants of Rnq1.Pathogenic polyglutamine tracts are potent inducers of spontaneous Sup35 and Rnq1 amyloidogenesis.Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register.Prion diseases and their biochemical mechanisms.
P2860
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P2860
Structural insights into a yeast prion illuminate nucleation and strain diversity
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structural insights into a yeast prion illuminate nucleation and strain diversity
@ast
Structural insights into a yeast prion illuminate nucleation and strain diversity
@en
Structural insights into a yeast prion illuminate nucleation and strain diversity
@nl
type
label
Structural insights into a yeast prion illuminate nucleation and strain diversity
@ast
Structural insights into a yeast prion illuminate nucleation and strain diversity
@en
Structural insights into a yeast prion illuminate nucleation and strain diversity
@nl
prefLabel
Structural insights into a yeast prion illuminate nucleation and strain diversity
@ast
Structural insights into a yeast prion illuminate nucleation and strain diversity
@en
Structural insights into a yeast prion illuminate nucleation and strain diversity
@nl
P2860
P356
P1433
P1476
Structural insights into a yeast prion illuminate nucleation and strain diversity
@en
P2093
Rajaraman Krishnan
P2860
P2888
P304
P356
10.1038/NATURE03679
P407
P577
2005-06-01T00:00:00Z
P5875
P6179
1043456603