Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients.
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Molecular pathogenesis and clinical management of Fanconi anemiaMissing Cells: Pathophysiology, Diagnosis, and Management of (Pan)Cytopenia in ChildhoodFanconi anemia and the cell cycle: new perspectives on aneuploidyHow cell death shapes cancerConcise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cellsChromosomal aberrations associated with clonal evolution and leukemic transformation in fanconi anemia: clinical and biological implications.Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process.Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells.Damage control and its costs: BM failure in Fanconi anemia stems from overactive p53/p21.BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 CellsCell cycle control in acute myeloid leukemia.FANCA safeguards interphase and mitosis during hematopoiesis in vivo.Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA DamageDNA interstrand crosslink repair and cancer.SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem CellsThe Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation.Fanconi anaemia: from a monogenic disease to sporadic cancer.Stress and DNA repair biology of the Fanconi anemia pathwayThe Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.Cytokinesis failure and attenuation: new findings in Fanconi anemia.Fancd2 and p21 function independently in maintaining the size of hematopoietic stem and progenitor cell pool in mice.USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation.Stem Cell Therapy for Fanconi Anemia.Identification of potentially oncogenic alterations from tumor-only samples reveals Fanconi anemia pathway mutations in bladder carcinomas.Reduced recruitment of 53BP1 during interstrand crosslink repair is associated with genetically inherited attenuation of mitomycin C sensitivity in a family with Fanconi anemia.TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice.Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell Proliferation.A small molecule p53 activator attenuates Fanconi anemia leukemic stem cell proliferation.Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia
P2860
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P2860
Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
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2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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Spontaneous abrogation of the ...... is in Fanconi anemia patients.
@ast
Spontaneous abrogation of the ...... is in Fanconi anemia patients.
@en
Spontaneous abrogation of the ...... is in Fanconi anemia patients.
@nl
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label
Spontaneous abrogation of the ...... is in Fanconi anemia patients.
@ast
Spontaneous abrogation of the ...... is in Fanconi anemia patients.
@en
Spontaneous abrogation of the ...... is in Fanconi anemia patients.
@nl
prefLabel
Spontaneous abrogation of the ...... is in Fanconi anemia patients.
@ast
Spontaneous abrogation of the ...... is in Fanconi anemia patients.
@en
Spontaneous abrogation of the ...... is in Fanconi anemia patients.
@nl
P2093
P2860
P50
P356
P1476
Spontaneous abrogation of the ...... is in Fanconi anemia patients.
@en
P2093
Catherine Dubois d'Enghien
Corinne Pondarre
Delphine Briot
Delphine Chamousset
Hans Joenje
Jean Soulier
Jérôme Larghero
Maria-Elena Noguera
Nadia Vasquez
Raphael Ceccaldi
P2860
P304
P356
10.1172/JCI43836
P407
P577
2010-12-22T00:00:00Z