SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse. - Wikidata - wikimedia - TriplyDB

SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse.

SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse.

http://www.wikidata.org/entity/Q34438640

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Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process?Redox Characterization of Functioning Skeletal Muscle Mechanisms of Muscle Denervation in Aging: Insights from a Mouse Model of Amyotrophic Lateral Sclerosis SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis Copper-zinc superoxide dismutase-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis induced with myelin oligodendrocyte glycoprotein 35-55 Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease A phosphodiesterase 2A isoform localized to mitochondria regulates respiration A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity Sclareol inhibits cell proliferation and sensitizes cells to the antiproliferative effect of bortezomib via upregulating the tumor suppressor caveolin-1 in cervical cancer cells.SOD1, an unexpected novel target for cancer therapy Endoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapy The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.Superoxide dismutases and superoxide reductases.Mitochondrial Ccs1 contains a structural disulfide bond crucial for the import of this unconventional substrate by the disulfide relay system In vivo pathogenic role of mutant SOD1 localized in the mitochondrial intermembrane space Reverse engineering human neurodegenerative disease using pluripotent stem cell technology.Is SOD1 loss of function involved in amyotrophic lateral sclerosis?Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase.SOD2 to SOD1 switch in breast cancer.Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice SOD1 and mitochondria in ALS: a dangerous liaison.Mitochondrial disulfide relay: redox-regulated protein import into the intermembrane space.The ultimate question: why do axons degenerate? A tribute to the work and mentorship of John W. Griffin, MD.Oxidative folding in the mitochondrial intermembrane space in human health and disease.The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?Revisiting an age-old question regarding oxidative stress.The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis.Targeting mitochondrial metal dyshomeostasis for the treatment of neurodegeneration.Redox homeostasis and age-related deficits in neuromuscular integrity and function.Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-mediated Inhibition of Mitochondrial Respiration.Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol.Unraveling new functions of superoxide dismutase using yeast model system: Beyond its conventional role in superoxide radical scavenging.Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy Impaired copper and iron metabolism in blood cells and muscles of patients affected by copper deficiency myeloneuropathy.Reply: Two novel mutations in conserved codons indicate that CHCHD10 is a gene associated with motor neuron disease.A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle.Protein Misfolding in Prion and Prion-Like Diseases: Reconsidering a Required Role for Protein Loss-of-Function.

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SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse.

http://www.wikidata.org/entity/Q34438640

description

2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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SOD1 targeted to the mitochond ...... hy in the Sod1 knockout mouse.

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SOD1 targeted to the mitochond ...... hy in the Sod1 knockout mouse.

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SOD1 targeted to the mitochond ...... hy in the Sod1 knockout mouse.

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Anissa Igoudjil

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Giovanni Manfredi

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Jason M Hansen

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Jonathan D Glass

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Jordi Magrané

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Lindsey R Fischer

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Yingjie Li

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P2860

Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1

Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

The mitochondrial inner membrane protein mitofilin controls cristae morphology

Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase

A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage.

Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression

Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)

Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy

Complex III releases superoxide to both sides of the inner mitochondrial membrane

Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals

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196-209

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10.1093/BRAIN/AWQ314

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Pt 1

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134

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2010-11-14T00:00:00Z

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47793949

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21078595

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3009841

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