Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition. - Wikidata - wikimedia - TriplyDB

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.

http://www.wikidata.org/entity/Q34439328

about

Breaking bad: The mutagenic effect of DNA repair Lagging-strand replication shapes the mutational landscape of the genome Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers Replicative DNA polymerase δ but not ε proofreads errors in Cis and in Trans Polymerase δ replicates both strands after homologous recombination-dependent fork restart Eukaryotic genome instability in light of asymmetric DNA replication APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication Who Is Leading the Replication Fork, Pol ε or Pol δ?Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelity The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis Eukaryotic Mismatch Repair in Relation to DNA Replication A high-throughput assay for quantitative measurement of PCR errors.Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation.Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects.Volatility of Mutator Phenotypes at Single Cell Resolution dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae.Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis.Extremely Rare Polymorphisms in Saccharomyces cerevisiae Allow Inference of the Mutational Spectrum Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.Stimulation of Chromosomal Rearrangements by Ribonucleotides.Mechanisms of glycosylase induced genomic instability Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools.The Effect of Local Sequence Context on Mutational Bias of Genes Encoded on the Leading and Lagging Strands.Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.Mutation at a distance caused by homopolymeric guanine repeats in Saccharomyces cerevisiae The topography of mutational processes in breast cancer genomes.Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand.DNA Polymerases Divide the Labor of Genome Replication.APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context.Eukaryotic DNA Replication Fork.MutSα maintains the mismatch repair capability by inhibiting PCNA unloading.Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.Polymerase ζ Activity Is Linked to Replication Timing in Humans: Evidence from Mutational Signatures.RNA biology of disease-associated microsatellite repeat expansions.Arranging eukaryotic nuclear DNA polymerases for replication: Specific interactions with accessory proteins arrange Pols α, δ, and ϵ in the replisome for leading-strand and lagging-strand DNA replication.DNA mismatch repair preferentially protects genes from mutation.Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae.

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Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.

http://www.wikidata.org/entity/Q34439328

description

2014 nî lūn-bûn

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2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Heterogeneous polymerase fidel ...... ome variation and composition.

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Heterogeneous polymerase fidel ...... ome variation and composition.

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Heterogeneous polymerase fidel ...... ome variation and composition.

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Heterogeneous polymerase fidel ...... ome variation and composition.

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Heterogeneous polymerase fidel ...... ome variation and composition.

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Genome Research

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Heterogeneous polymerase fidel ...... nome variation and composition

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Adam B Burkholder

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Alan B Clark

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David C Fargo

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David M MacAlpine

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Heather K MacAlpine

http://www.w3.org/2001/XMLSchema#string

Scott A Lujan

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Mutation rates differ among regions of the mammalian genome

Rates of spontaneous mutation

Sequence logos: a new way to display consensus sequences

Mutational heterogeneity in cancer and the search for new cancer-associated genes

OriDB, the DNA replication origin database updated and extended

The rate and molecular spectrum of spontaneous mutations in Arabidopsis thaliana

Yeast DNA polymerase epsilon participates in leading-strand DNA replication

WebLogo: A Sequence Logo Generator

Unique error signature of the four-subunit yeast DNA polymerase epsilon.

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1751-1764

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scholarly article

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10.1101/GR.178335.114

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11

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24

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Dmitry A. Gordenin

Anders R. Clausen

Piotr A Mieczkowski

Thomas A Kunkel

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2014-09-12T00:00:00Z

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265608273

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25217194

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4216917

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