Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. - Wikidata - wikimedia - TriplyDB

Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents.

Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents.

http://www.wikidata.org/entity/Q34440814

about

LICC: L-BLP25 in patients with colorectal carcinoma after curative resection of hepatic metastases: a randomized, placebo-controlled, multicenter, multinational, double-blinded phase II trial A minimal fragment of MUC1 mediates growth of cancer cells MUC1* mediates the growth of human pluripotent stem cells The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH MUC1-C Oncoprotein Blocks Terminal Differentiation of Chronic Myelogenous Leukemia Cells by a ROS-Mediated Mechanism Mucins in cancer: function, prognosis and therapy MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1 Lung cancer vaccines MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90 Novel MUC1 aptamer selectively delivers cytotoxic agent to cancer cells in vitro Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells MUC1 expression by human airway epithelial cells mediates Pseudomonas aeruginosa adhesion.Protection of cisplatin cytotoxicity by an inactive cyclin-dependent kinase.Transmembrane and secreted MUC1 probes show trafficking-dependent changes in O-glycan core profiles.O-glycan inhibitors generate aryl-glycans, induce apoptosis and lead to growth inhibition in colorectal cancer cell lines.MUC1 mucin interacts with calcium-modulating cyclophilin ligand.MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer.Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells.Mucin 1 C-terminal subunit oncoprotein is a target for small-molecule inhibitors.The cytoplasmic domain of MUC1 induces hyperplasia in the mammary gland and correlates with nuclear accumulation of β-catenin.Expression of the transmembrane mucins, MUC1, MUC4 and MUC16, in normal endometrium and in endometriosis.MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion RNA interference suppression of mucin 5AC (MUC5AC) reduces the adhesive and invasive capacity of human pancreatic cancer cells Muc1 cell surface mucin attenuates epithelial inflammation in response to a common mucosal pathogen.Intrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression.Survival of human multiple myeloma cells is dependent on MUC1 C-terminal transmembrane subunit oncoprotein function.Impact of MUC1 mucin downregulation in the phenotypic characteristics of MKN45 gastric carcinoma cell line MUCIN 1 ONCOPROTEIN EXPRESSION IS SUPPRESSED BY THE miR-125b ONCOMIR Protein mislocalization: mechanisms, functions and clinical applications in cancer.MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation.EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1.Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors.Altered Mucins (MUC) trafficking in benign and malignant conditions.MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization.MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines.

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Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents.

http://www.wikidata.org/entity/Q34440814

description

2004 nî lūn-bûn

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2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2004 թվականի փետրվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Human MUC1 carcinoma-associate ...... o genotoxic anticancer agents.

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Human MUC1 carcinoma-associate ...... o genotoxic anticancer agents.

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Human MUC1 carcinoma-associate ...... o genotoxic anticancer agents.

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Human MUC1 carcinoma-associate ...... o genotoxic anticancer agents.

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Human MUC1 carcinoma-associate ...... o genotoxic anticancer agents.

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Human MUC1 carcinoma-associate ...... o genotoxic anticancer agents.

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Human MUC1 carcinoma-associate ...... o genotoxic anticancer agents.

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Human MUC1 carcinoma-associate ...... o genotoxic anticancer agents.

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Human MUC1 carcinoma-associate ...... o genotoxic anticancer agents.

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Human MUC1 carcinoma-associate ...... o genotoxic anticancer agents.

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Deepak Raina

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Donald Kufe

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Dongshu Chen

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Jian Ren

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Lei Huang

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Naoki Agata

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Surender Kharbanda

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Wei-hsuan Yu

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Wen Chen

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Yongqing Li

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P2860

Molecular characterization of mitochondrial apoptosis-inducing factor

Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70

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163-175

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10.1016/S1535-6108(04)00020-0

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2

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5

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4217165

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